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Titolo:
EARLY EXPRESSION OF SMOOTH-PURSUIT EYE-MOVEMENT ABNORMALITIES IN CHILDREN OF SCHIZOPHRENIC PARENTS
Autore:
ROSS RG; HOMMER D; RADANT A; ROATH M; FREEDMAN R;
Indirizzi:
BOX C268-71,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR DENVER CO 00000 NIAAA BETHESDA MD 00000 UNIV WASHINGTON SEATTLE WA 98195
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 7, volume: 35, anno: 1996,
pagine: 941 - 949
SICI:
0890-8567(1996)35:7<941:EEOSEA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOTYPAL PERSONALITY-DISORDER; QUANTITATIVE ASSESSMENT; TRACKING DYSFUNCTION; MONOZYGOTIC TWINS; DISCORDANT TWINS; VISUAL TRACKING; MONKEY; RELATIVES; FAMILY; MODEL;
Keywords:
EYE MOVEMENTS; SMOOTH PURSUIT; SCHIZOPHRENIA; CHILDREN; AT-RISK; ENDOPHENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Ross et al., "EARLY EXPRESSION OF SMOOTH-PURSUIT EYE-MOVEMENT ABNORMALITIES IN CHILDREN OF SCHIZOPHRENIC PARENTS", Journal of the American Academy of Child and Adolescent Psychiatry, 35(7), 1996, pp. 941-949

Abstract

Objective: Disordered smooth-pursuit eye movements (SPEM) and, specifically, small anticipatory saccades that disrupt SPEM have been hypothesized to be a marker of genetic vulnerability to schizophrenia. This study compares SPEM in children of schizophrenic parents with normallydeveloping control children to assess whether SPEM abnormalities are also present in a subset of at-risk children. Method: With infrared oculography, SPEM was examined in 13 children of schizophrenic parents and 19 normally developing controls (aged 6 to 15 years). Measures of smooth-pursuit gain and root mean square error were used in addition tomore specific measures of catch-up saccades and anticipatory saccades. Results: Children of schizophrenic parents differed from normally developing controls on gain and root mean square error, but not on catch-up saccades. Small anticipatory saccades were significantly more frequent in the at-risk group. The percentage of total eye movements due to anticipatory saccades identified 54% of the at-risk group (compared with none of the control group) as performing more than two standard deviations above (worse than) the control mean. Conclusions: The presence of increased anticipatory saccades is evidence for an oculomotor dysfunction that may be a phenotype of the genetic risk for schizophrenia, expressed years prior to the possible development of clinical illness.

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Documento generato il 19/09/20 alle ore 08:37:34