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Titolo:
DYSFUNCTION OF THE E-CADHERIN CATENIN CELL-ADHESION CASCADE IN EPITHELIAL CANCERS (REVIEW)/
Autore:
RAFTOPOULOS IS; KOURAKLIS G;
Indirizzi:
122 VASILISIS SOPHIAS AVE GR-11526 ATHENS GREECE UNIV ATHENS,LAIKON GEN HOSP,SCH MED,DEPT PROPEDEUT SURG 2 GR-115215 ATHENS GREECE
Titolo Testata:
Oncology Reports
fascicolo: 4, volume: 3, anno: 1996,
pagine: 793 - 803
SICI:
1021-335X(1996)3:4<793:DOTECC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVOMORULIN-CATENIN COMPLEX; HUMAN PROSTATE-CANCER; MOLECULE E-CADHERIN; ALPHA-CATENIN; CYTOPLASMIC DOMAIN; TUMOR PROGRESSION; GASTRIC-CANCER; BREAST-CANCER; BETA-CATENIN; TYROSINE PHOSPHORYLATION;
Keywords:
E-CADHERIN; CATENINS; EPITHELIAL CANCERS; DIFFERENTIATION; METASTASIS; PROGNOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
112
Recensione:
Indirizzi per estratti:
Citazione:
I.S. Raftopoulos e G. Kouraklis, "DYSFUNCTION OF THE E-CADHERIN CATENIN CELL-ADHESION CASCADE IN EPITHELIAL CANCERS (REVIEW)/", Oncology Reports, 3(4), 1996, pp. 793-803

Abstract

The E-cadherin/catenin complex is the major adhesion system that maintains the intercellular contacts in all epithelial cells. E-cadherin mediates Ca++-dependent, homotypic cell-cell adhesion and associates with the cytoskeleton through the interaction with three cytoplasmic proteins, called catenins. Dysfunction of the E-cadherin/catenin complex occurs frequently in the epithelial cancers and is correlated with dedifferentiation, advanced stage and poor prognosis. Additionally, loss of E-cadherin and alpha-catenin expression in epithelial cells in vitro, is associated with fibroblastic morphology and increased invasiveness. E-cadherin and alpha-catenin might be regarded as tumor suppressormolecules with potential diagnostic and prognostic value in epithelial cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:11:32