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Titolo:
SEROUS AND MUCINOUS BORDERLINE TUMORS OF THE OVARY - A CLINICOPATHOLOGICAL AND DNA-PLOIDY STUDY OF 102 CASES
Autore:
KUOPPALA T; HEINOLA M; AINE R; ISOLA J; HEINONEN PK;
Indirizzi:
UNIV TAMPERE,SCH MED,BOX 607 FIN-33101 TAMPERE FINLAND UNIV TAMPERE,SCH MED FIN-33101 TAMPERE FINLAND TAMPERE UNIV,DEPT OBSTET & GYNECOL FIN-33101 TAMPERE FINLAND TAMPERE UNIV,DEPT PATHOL FIN-33101 TAMPERE FINLAND
Titolo Testata:
International journal of gynecological cancer
fascicolo: 4, volume: 6, anno: 1996,
pagine: 302 - 308
SICI:
1048-891X(1996)6:4<302:SAMBTO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW-CYTOMETRY; TREATMENT MODALITIES; PERITONEAL IMPLANTS; MALIGNANCY; CARCINOMA; FEATURES; PROGNOSIS;
Keywords:
BORDERLINE; CA125; FLOW CYTOMETRY; MUCINOUS; OVARIAN TUMORS; SEROUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Kuoppala et al., "SEROUS AND MUCINOUS BORDERLINE TUMORS OF THE OVARY - A CLINICOPATHOLOGICAL AND DNA-PLOIDY STUDY OF 102 CASES", International journal of gynecological cancer, 6(4), 1996, pp. 302-308

Abstract

One-hundred and two patients with epithelial borderline ovarian tumors treated at Tampere University Hospital between January 1965 and September 1991 were evaluated. There were 48 patients with serous tumors and 54 with mucinous tumors. Ninety-three (91%) patients had clinical stage I and nine had stage III disease. Abdominal hysterectomy and bilateral salpingo-oophorectomy were performed in 70% of the patients. Forty percent of those with serous and 20% with mucinous tumors were operated conservatively. After conservative surgery six patients had a total of 10 deliveries and none of these had a recurrence. Seven patientsreceived chemotherapy, none had radiation therapy. An aneuploid DNA pattern was identified in 8.2% of 85 specimens studied and a high S-phase fraction was found in 8.6% of 81 specimens studied. DNA measurementfailed to identify the malignantly behaving tumors. Elevated preoperative serum levels of CA125 were found in 10 (63%) out of 16 cases studied. All of them dropped postoperatively to normal. During the follow-up period (mean 11.6 years, range 4.5-29.7 years) 22 patients died butin 17 of them death was unrelated to ovarian tumor. The corrected (borderline malignancies related) 5-year survival rate was 100% in patients with serous tumor and 96% with mucinous tumor, 25-year survival rate was 97% and 91%, respectively. There was no difference between the serous and mucinous groups. Our results show that ovarian borderline tumors have a good prognosis. Quite conservative therapy is often enough, especially in low-stage disease in young women who want to retain their fertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 09:53:06