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Titolo:
ANTIVIRAL ACTIVITIES OF TRAGACANTHIN POLYSACCHARIDES AN PUNTA-TORO VIRUS-INFECTIONS IN MICE
Autore:
SMEE DF; SIDWELL RW; HUFFMAN JH; HUGGINS JW; KENDE M; VERBISCAR AJ;
Indirizzi:
UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,INST ANTIVIRAL RES LOGAN UT84322 USA,MED RES INST INFECT DIS,DIV VIROL FT DETRICK MD 21702 ANVER BIOSCI DESIGN INC SIERRA MADRE CA 00000
Titolo Testata:
Chemotherapy
fascicolo: 4, volume: 42, anno: 1996,
pagine: 286 - 293
SICI:
0009-3157(1996)42:4<286:AAOTPA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE;
Keywords:
ANTIVIRAL; ASTRAGALUS; TRAGACANTHIN; POLYSACCHARIDE; BUNYAVIRUS; PHLEBOVIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Smee et al., "ANTIVIRAL ACTIVITIES OF TRAGACANTHIN POLYSACCHARIDES AN PUNTA-TORO VIRUS-INFECTIONS IN MICE", Chemotherapy, 42(4), 1996, pp. 286-293

Abstract

Tragacanthin polysaccharides from Astragalus brachycentrus (AV208) and Astragalus echidnaeformis (AV212) plants, which are devoid of in vitro antiviral activity, were evaluated in a mouse model of Punta Toro virus (PTV) infection. The PTV (a phlebovirus member of the Bunyaviridae family of viruses) is a model for studying the treatment of Rift Valley fever and hantavirus infections. Single intraperitoneal treatmentswith 12.5-200 mg/kg/day doses of AV212 given 24 h before or 4 and 24 h after virus inoculation protected the majority of mice from mortality. Single treatments with AV208 were ineffective when given 24 h before the virus challenge; however, protection was afforded when treatments were administered at 4 and 24 h following virus inoculation. In a follow-up study, AV208 treatments of 1.6-50 mg/kg/day given 24 h subsequent to virus exposure caused reductions in mortality, liver infection scores, liver and spleen virus titers, and serum transaminases, The polysaccharides did not activate lymphocytes or natural killer cells, nor was interferon induced in treated mice. However, mice pretreated with fumed silica (a macrophage poison) and infected with the PTV were not protected by subsequent administration of AV208 or AV212 at 50 mg/kg, providing evidence that activation of peritoneal macrophages by the polysaccharides affords protection to infected animals. These compounds should be considered for the potential treatment of significant human infections induced by bunyaviruses and hantaviruses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:42:06