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Titolo:
IN-UTERO ALLOGENEIC HEMATOPOIETIC STEM-CELL TRANSPLANTATION TO INDUCETOLERANCE
Autore:
HAJDU K; TANIGAWARA S; MCLEAN LK; COWAN MJ; GOLBUS MS;
Indirizzi:
UNIV CALIF SAN FRANCISCO,MED CTR,DEPT OBSTET GYNECOL & REPROD SCI,REPROD GENET UNIT,U-262 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,MED CTR,DEPT OBSTET GYNECOL & REPROD SCI,REPROD GENET UNIT SAN FRANCISCO CA 94143
Titolo Testata:
Fetal diagnosis and therapy
fascicolo: 4, volume: 11, anno: 1996,
pagine: 241 - 248
SICI:
1015-3837(1996)11:4<241:IAHSTT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Keywords:
TRANSPLANTATION; TOLERANCE; FETAL LIVER CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
K. Hajdu et al., "IN-UTERO ALLOGENEIC HEMATOPOIETIC STEM-CELL TRANSPLANTATION TO INDUCETOLERANCE", Fetal diagnosis and therapy, 11(4), 1996, pp. 241-248

Abstract

We studied the efficacy of in utero hematopoietic stem cell transplantation and the ability of such transplantation to induce tolerance in a fetal normal mouse allogeneic model. In 9 of the 162 surviving recipients (5.6%), cells of donor origin were detected after birth, The highest engraftment rate was achieved by transplanting fetal liver cells in a relatively high dose (>10(6) cells/fetal gram), Skin grafting wasperformed to determine the presence of prenatally induced tolerance, Only those mice which showed evidence of chimerism became tolerant to skin derived from the prenatal donor's strain while remaining competent to reject a skin transplant from a third strain. Tolerant mice couldhave significant chimerism reestablished by utilizing monoclonal antibody specific for the recipient H-2 antigen as conditioning for IV fetal stem cell. retransplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:13:51