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Titolo:
THE IN-VIVO INTERACTION BETWEEN FLAVONE ACETIC-ACID AND HYPERTHERMIA
Autore:
HORSMAN MR; SAMPSON LE; CHAPLIN DJ; OVERGAARD J;
Indirizzi:
DANISH CANC SOC,DEPT EXPT CLIN ONCOL,NORREBROGADE 44,BLDG 5 DK-8000 AARHUS C DENMARK MT VERNON HOSP,CANC RES TRUST,GRAY LAB NORTHWOOD HA6 2JR MIDDX ENGLAND
Titolo Testata:
International journal of hyperthermia
fascicolo: 6, volume: 12, anno: 1996,
pagine: 779 - 789
SICI:
0265-6736(1996)12:6<779:TIIBFA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MAMMARY-CARCINOMA INVIVO; BLOOD-FLOW; HYDRALAZINE; ENHANCEMENT; CELLS; MICE; NSC-347512; CANCER; INDUCTION;
Keywords:
HYPERTHERMIA; FLAVONE ACETIC ACID; C3H MOUSE MAMMARY CARCINOMA; NORMAL FOOT SKIN; TUMOR NECROSIS FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Horsman et al., "THE IN-VIVO INTERACTION BETWEEN FLAVONE ACETIC-ACID AND HYPERTHERMIA", International journal of hyperthermia, 12(6), 1996, pp. 779-789

Abstract

The in vivo interaction between flavone acetic acid (FAA) and hyperthermia was studied in a C3H mammary carcinoma grown in the feet of female CDF1 mice and in normal foot skin. FAA was intraperitoneally injected prior to local tissue heating in restrained non-anaesthetized animals. Alone, FAA at doses of 100 mg/kg and above, inhibited tumour growth in a dose-dependent fashion. FAA also enhanced the tumour response to heat, the effect being dependent on both the time interval between the two modalities and the FAA dose, the greatest effect occurring whenFAA doses of greater than or equal to 150 mg/kg preceeded heat by 3-48 h. These effects of FAA correlated with the drug's ability to decrease tumour blood perfusion measured using the RbCl extraction procedure. Injecting 150 mg/kg FAA 3 h before heating (42.7 degrees C) resultedin a 2.2-fold increase in tumour heat damage, but had little effect on the response of normal foot skin in non-tumour-bearing mice. However, this treatment gave a 2.0-fold increase in normal tissue damage whenthe skin experiments were repeated in tumour-bearing animals. These effects in skin occurred in the absence of any blood perfusion changes,but appeared to be associated with FAA-induced TNF-alpha production.

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Documento generato il 05/12/20 alle ore 13:18:38