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Titolo:
GROWTH-FACTORS AND INTRAUTERINE GROWTH-RETARDATION .2. SERUM GROWTH-HORMONE, INSULIN-LIKE GROWTH-FACTOR (IGF)I, AND IGF-BINDING PROTEIN-3 LEVELS IN CHILDREN WITH INTRAUTERINE GROWTH-RETARDATION COMPARED WITH NORMAL CONTROL SUBJECTS - PROSPECTIVE-STUDY FROM BIRTH TO 2 YEARS OF AGE
Autore:
LEGER J; NOEL M; LIMAL JM; CZERNICHOW P;
Indirizzi:
HOP ROBERT DEBRE,PEDIAT ENDOCRINOL UNIT,48 BD SERURIER F-75019 PARIS FRANCE HOP ROBERT DEBRE,PEDIAT ENDOCRINOL & DIABET UNIT F-75019 PARIS FRANCE HOP ANGERS,PEDIAT ENDOCRINOL UNIT ANGERS FRANCE
Titolo Testata:
Pediatric research
fascicolo: 1, volume: 40, anno: 1996,
pagine: 101 - 107
SICI:
0031-3998(1996)40:1<101:GAIG.S>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
UMBILICAL-CORD SERUM; FACTOR-I; SOMATOMEDIN-C; PROMOTING ACTIVITY; NEWBORN-INFANTS; HUMAN FETUS; FETAL RATS; WEIGHT; DIAGNOSIS; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J. Leger et al., "GROWTH-FACTORS AND INTRAUTERINE GROWTH-RETARDATION .2. SERUM GROWTH-HORMONE, INSULIN-LIKE GROWTH-FACTOR (IGF)I, AND IGF-BINDING PROTEIN-3 LEVELS IN CHILDREN WITH INTRAUTERINE GROWTH-RETARDATION COMPARED WITH NORMAL CONTROL SUBJECTS - PROSPECTIVE-STUDY FROM BIRTH TO 2 YEARS OF AGE", Pediatric research, 40(1), 1996, pp. 101-107

Abstract

The aim of this study was to describe serum GH: IGF-I, and IGF binding protein (BP) 3 levels at birth and during the first 2 y of life in intrauterine growth-retarded (IUGR) children and to correlate these hormonal values with auxologic parameters noted during this period to investigate their predictive value on the postnatal growth pattern. Threehundred and seventeen children were included at birth and studied forauxologic and biologic parameters at birth, 3 and 30 d, and 3, 6, 12,18, and 24 mo of age, At birth, when analyzed according to gestational age, serum GH levels were increased (p = 0.0001) and serum IGF-I andIGFBP3 levels were decreased (p = 0.0001) in IUGR as compared with normal neonates. When two cohorts were established at birth as a function of the ponderal index (PI) (less than or equal to or >3rd percentile), serum IGF-I and IGFBP3 levels were found to be significantly reduced in the case of low PI. All parameters were within normal limits at 1mo of age and remained normal thereafter, During the first 3 mo of life, a positive correlation was found between IGF-I increment and weight gain (r = 0.28, p = 0.002), None of the biologic parameters at birthwere predictive either of later growth or of short stature at 2 y of age, In conclusion, low serum IGF-I and IGFBP3 levels at birth were related to fetal malnutrition and were not predictive parameters for later growth.

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Documento generato il 02/12/20 alle ore 17:54:56