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Titolo:
5-HT1A RECEPTOR ANTAGONISTS AND LORDOSIS BEHAVIOR
Autore:
UPHOUSE L; ANDRADE M; CALDAROLAPASTUSZKA M; JACKSON A;
Indirizzi:
TEXAS WOMANS UNIV,DEPT BIOL DENTON TX 76204
Titolo Testata:
Neuropharmacology
fascicolo: 4, volume: 35, anno: 1996,
pagine: 489 - 495
SICI:
0028-3908(1996)35:4<489:5RAALB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC 5-HT(1A) RECEPTORS; SEXUAL-BEHAVIOR; SELECTIVE ANTAGONIST; FEMALE RATS; AGONISTS; 8-OH-DPAT; SEROTONIN;
Keywords:
5-HT; BETA-ADRENOCEPTOR ANTAGONISTS; PROESTROUS FEMALES; OVARIECTOMIZED RATS; SEXUAL BEHAVIOR; SUBOPTIMAL HORMONE PRIMING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L. Uphouse et al., "5-HT1A RECEPTOR ANTAGONISTS AND LORDOSIS BEHAVIOR", Neuropharmacology, 35(4), 1996, pp. 489-495

Abstract

In proestrous rats, serotonin 1A (5-HT1A) receptor agonists inhibit lordosis behavior within 5-15 min following infusion into the ventromedial nucleus of the hypothalamus (VMN). In the present report, the lordosis-inhibiting effects of the 5-HT1A agonist [(+)8-hydroxy-2-(di-n-propylamino) tetralin) (8-OH-DPAT] were shown to be attenuated with 5-HT1A receptor antagonists. Two compounds, propranolol and pindolol, thatfunction as both beta-adrenergic and 5-HT1A receptor antagonists, and(+) WAY100135 (chiral 2-methoxy)phenyl)piperazinyl)-1-phenylpropionamide dihydrochloride, quarter hydrate), a more selective 5-HT1A receptor antagonist, were found to reduce the lordosis-inhibiting effects of 8-OH-DPAT infusion into the VMN. Proestrous rats were co-infused into the VMN with 200 ng 8-OH-DPAT plus 1000 ng or 2000 ng pindolol, 1000 ng or 2000 ng propranolol, or 2000 ng (+) WAY100135. Go-infusion with 1000 ng or 2000 ng pindolol attenuated the inhibitory effects of 8-OH-DPAT; co-infusion of 1000 ng, but not 2000 ng, propranolol, reduced theeffects of 8-OH-DPAT; and co-infusion with 2000 ng (+) WAY100135 attenuated the effects of 8-OH-DPAT. Bilateral VMN infusion with 2500 ng () WAY100135 facilitated lordosis behavior in suboptimally, hormone-primed ovariectomized rats. These findings strengthen the argument that the inhibitory effect of 5-HT1A receptor agonists on lordosis behavioris the result of their activation of VMN 5-HT1A receptors. (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:19:33