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Titolo:
LARGE-DOSE PROPOFOL ALONE IN ADULT EPILEPTIC PATIENTS - ELECTROCORTICOGRAPHIC RESULTS
Autore:
CHENG MA; TEMPELHOFF R; SILBERGELD DL; THEARD MA; HAINES SK; MILLER JW;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT ANESTHESIOL,660 S EUCLID,BOX 8054 ST LOUIS MO 63141 WASHINGTON UNIV,SCH MED,DEPT ANESTHESIOL ST LOUIS MO 63141 WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG ST LOUIS MO 63141 WASHINGTON UNIV,SCH MED,DEPT NEUROL ST LOUIS MO 63141
Titolo Testata:
Anesthesia and analgesia
fascicolo: 1, volume: 83, anno: 1996,
pagine: 169 - 174
SICI:
0003-2999(1996)83:1<169:LPAIAE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROUS-OXIDE; ANESTHESIA; SEIZURES; ELECTROENCEPHALOGRAM; SEDATION; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Cheng et al., "LARGE-DOSE PROPOFOL ALONE IN ADULT EPILEPTIC PATIENTS - ELECTROCORTICOGRAPHIC RESULTS", Anesthesia and analgesia, 83(1), 1996, pp. 169-174

Abstract

The primary objective of this study was to evaluate the electrophysiologic effects of large-dose propofol, used as the sole anesthetic in patients with epilepsy. Nine patients with medically intractable complex partial epilepsy undergoing a three-stage approach to the surgical management of epilepsy were recruited. Stage I involved placement of the intracranial electrode array, while Stage II consisted of extraoperative localization of the seizure focus. The patients were studied during induction of anesthesia for Stage III (removal of electrodes and resection of seizure focus). Unpremedicated patients were induced with apropofol infusion (0.5 mg.kg(-1).min(-1)) until one of the following occurred: 1) electrical seizure activity, 2) burst suppression, or 3) total dose of 10 mg/ kg. Electrocorticography (ECoG) was recorded continuously during this period. Two patients were excluded from the studyafter experiencing delayed awakening after the Stage I procedure. Both had received propofol along with other anesthetics. No ECoG evidenceof seizure activity was detected in the seven patients completing thestudy. Burst suppression was attained in six patients using a mean dose of 5.7 mg/kg +/- 2.6. We conclude that large-dose propofol alone does not trigger electrical epileptiform activity on the ECoG of seizurepatients.

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Documento generato il 30/11/20 alle ore 17:33:02