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Titolo:
QUANTITATIVE CARDIAC PERFUSION - A NONINVASIVE SPIN-LABELING METHOD THAT EXPLOITS CORONARY VESSEL GEOMETRY
Autore:
REEDER SB; ATALAY MK; MCVEIGH ER; ZERHOUNI EA; FORDER JR;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,217 TRAYLOR BLDG,720 RUTLAND AVE BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN BALTIMORE MD 21205
Titolo Testata:
Radiology
fascicolo: 1, volume: 200, anno: 1996,
pagine: 177 - 184
SICI:
0033-8419(1996)200:1<177:QCP-AN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; POSITRON-EMISSION TOMOGRAPHY; ARTERIAL WATER; GRADIENT-ECHO; INVERSION; QUANTIFICATION; HETEROGENEITY; EXERCISE; CONTRAST; RAT;
Keywords:
HEART; MAGNETIC RESONANCE (MR), PERFUSION STUDY; MAGNETIC RESONANCE (MR), TECHNOLOGY; MYOCARDIUM, BLOOD SUPPLY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Reeder et al., "QUANTITATIVE CARDIAC PERFUSION - A NONINVASIVE SPIN-LABELING METHOD THAT EXPLOITS CORONARY VESSEL GEOMETRY", Radiology, 200(1), 1996, pp. 177-184

Abstract

PURPOSE: To quantitate myocardial arterial perfusion with a noninvasive magnetic resonance (MR) imaging technique that exploits the geometry of coronary vessel anatomy. MATERIALS AND METHODS: MR imaging-was performed with a spin-labeling method in six arrested rabbit hearts at 4.7 T. Selective inversion of magnetization in the short-axis imaging section along with all myocardium apical to that section produces signal enhancement from arterial perfusion. A linescan protocol was used for validation of now enhancement. Flow was quantitated from two images and validated with spin-echo (SE) imaging. Regional perfusion defects were created by means of coronary artery ligation and delineated with gadolinium-enhanced imaging. RESULTS: Linescan estimates of T1 obtained at physiologic flows agreed with model predictions. Flow-induced signal enhancement measured on-SE-images also agreed with expected values. Finally, perfusion abnormalities created by means of coronary arteryligation were detected. CONCLUSION: This spin-labeling method-provides quantitative estimates of myocardial arterial perfusion in this model and may hold promise for clinical applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:42:45