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Titolo:
RADIOIODINATED (AMINOSTYRYL)PYRIDINIUM (ASP) DYES - NEW CELL-MEMBRANEPROBES FOR LABELING MIXED LEUKOCYTES AND LYMPHOCYTES FOR DIAGNOSTIC-IMAGING
Autore:
LAMBERT C; MEASE RC; AVREN L; LE T; SABET H; MCAFEE JG;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,2300 EYE ST NW WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL WASHINGTON DC 20037 NIH BETHESDA MD 20802
Titolo Testata:
Nuclear medicine and biology
fascicolo: 4, volume: 23, anno: 1996,
pagine: 417 - 427
SICI:
0969-8051(1996)23:4<417:R((D-N>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE BACTERIAL-INFECTION; CHARGE-SHIFT PROBES; WHITE BLOOD-CELLS; IN-111 OXINE; AUTOLOGOUS LYMPHOCYTES; INFLAMMATORY LESIONS; MONOCLONAL-ANTIBODY; INVIVO; GRANULOCYTES; LOCALIZATION;
Keywords:
LEUKOCYTE LABELING; LYMPHOCYTE LABELING; (AMINOSTYRYL)PYRIDINIUM DYES; RADIOIODINATED CELL MEMBRANE PROBES; INFLAMMATION IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
C. Lambert et al., "RADIOIODINATED (AMINOSTYRYL)PYRIDINIUM (ASP) DYES - NEW CELL-MEMBRANEPROBES FOR LABELING MIXED LEUKOCYTES AND LYMPHOCYTES FOR DIAGNOSTIC-IMAGING", Nuclear medicine and biology, 23(4), 1996, pp. 417-427

Abstract

We prepared [I-125/I-131]iodo-(aminostyryl)pyridinium dyes from tributylstannyl precursors. ASP 7a and 7b labeled leukocytes ex vivo (70-94%) using saline with or without washing plasma from cells. Viability of peripheral blood lymphocytes (PBLs) (dogs, rats) and splenic lymphocytes (rats) labeled with 7a and 7b (71-82%) was unchanged after labeling (greater than or equal to 88%). Canine 7b leukocytes showed higher uptake in inflammatory lesions than did In-111-oxine leukocytes. At 3 h, aspirates contained more radioiodine than In-111 (1.65:1 to 22:1) and radioiodine was cell bound. ROI measurements (3 h) gave abscess to contralateral knee ratios of 12.3 and 10.6 for I-131-7b vs. 4.8 and 2.3 for In-111-oxine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:33:18