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Titolo:
PHARMACOKINETICS OF CIS-DIAMMINEDICHLOROPLATINUM(II) GIVEN AS LOW-DOSE AND HIGH-DOSE INFUSIONS
Autore:
KURIHARA N; KUBOTA T; HOSHIYA Y; OTANI Y; ANDO N; KUMAI K; KITAJIMA M;
Indirizzi:
KEIO UNIV,SCH MED,DEPT SURG,35 SHINANOMACHI TOKYO 160 JAPAN KEIO UNIV,SCH MED,DEPT SURG TOKYO 160 JAPAN
Titolo Testata:
Journal of surgical oncology
fascicolo: 2, volume: 62, anno: 1996,
pagine: 135 - 138
SICI:
0022-4790(1996)62:2<135:POCGAL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-CANCER; PHASE-II; NECK-CANCER; CISPLATIN; PLATINUM; HEAD; TRIAL;
Keywords:
CIS-DIAMMINEDICHLOROPLATINUM (II); LOW-DOSE CONSECUTIVE INFUSION; PHARMACOKINETICS; AREA UNDER THE CURVE (AUC); HOLDING TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
N. Kurihara et al., "PHARMACOKINETICS OF CIS-DIAMMINEDICHLOROPLATINUM(II) GIVEN AS LOW-DOSE AND HIGH-DOSE INFUSIONS", Journal of surgical oncology, 62(2), 1996, pp. 135-138

Abstract

A pharmacokinetic analysis of cis-diamminedichloroplatinum (IT) (DDP)was conducted comparing low-dose daily bolus infusions, and high-dosedrip infusions. Eight patients with gastric cancer were treated with low-dose daily bolus infusions of DDP to a total daily dose of 75 mg/m(2) bid for 5 days. Four patients with esophageal cancer and one patient with gastric cancer were treated with high-dose drip infusions of DDP to a total daily dose of 70-80 mg/m(2). Side effects were assessed in all the patients, and the platinum concentration in plasma was determined by an atomic absorption method. The peak plasma concentration (C-max) and area under the curve (AUC) were calculated in four cases ofthe low-dose therapy, and three cases of the high-dose therapy. The side effects of DDP were evaluated according to the World Health Organization (WHO) grading, paying particular attention to nausea/vomiting, appetite loss, renal toxicity, and bone marrow suppression. The incidence of nausea/vomiting and appetite loss was significantly reduced with low-dose daily bolus infusions when compared to the high-dose drip infusions. Bone marrow toxicity and renal toxicity were similar with both administration methods, although hydration was required for the high-dose drip infusions to prevent renal toxicity. The peak plasma concentration (C-max) of total and free platinum, and the area under the curve (AUC) of total platinum, were similar with both administration methods, while the AUC of free platinum was higher with the low-dose daily bolus infusions compared to the high-dose drip infusions. The time when the concentration of total platinum was >1 mu g per mi (holding time) was significantly longer with the high-dose drip infusions than with the low-dose daily bolus infusions. The present study suggests thatlow-dose daily bolus infusions of DDP would be useful in reducing gastrointestinal toxicity, without reducing the area under the curve which is important for antitumor activity. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:53:22