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Titolo:
ELEVATED CONCENTRATION AND BIOLOGIC ACTIVITY OF MONOCYTE CHEMOTACTIC PROTEIN-1 IN THE PERITONEAL-FLUID OF PATIENTS WITH ENDOMETRIOSIS
Autore:
AKOUM A; LEMAY A; MCCOLL S; TURCOTLEMAY L; MAHEUX R;
Indirizzi:
HOP ST FRANCOIS ASSISE,CTR RECH,LAB ENDOCRINOL REPROD,10 RUE ESPINAY,LOCAL D0-711 QUEBEC CITY PQ G1L 3L5 CANADA UNIV LAVAL ST FOY PQ G1K 7P4 CANADA
Titolo Testata:
Fertility and sterility
fascicolo: 1, volume: 66, anno: 1996,
pagine: 17 - 23
SICI:
0015-0282(1996)66:1<17:ECABAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CHEMOATTRACTANT PROTEIN-1; INFERTILE WOMEN; CELL-LINE; MACROPHAGES; INVITRO;
Keywords:
ENDOMETRIOSIS; CHEMOTACTIC FACTORS; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Akoum et al., "ELEVATED CONCENTRATION AND BIOLOGIC ACTIVITY OF MONOCYTE CHEMOTACTIC PROTEIN-1 IN THE PERITONEAL-FLUID OF PATIENTS WITH ENDOMETRIOSIS", Fertility and sterility, 66(1), 1996, pp. 17-23

Abstract

Objective: To estimate the concentration and the biologic activity ofmonocyte chemotactic protein-1 (MCP-1) in the peritoneal fluid (PF) of women with and without endometriosis. Design: A case control study was conducted. Setting: Gynecology clinic and Laboratories of endocrinology of reproduction and immunology. Patients: Women presenting for infertility, pelvic pain, or tubal ligation in which endometriosis was diagnosed at laparoscopy (n = 36) and normal fertile controls presenting for tubal ligation (n = 21). Interventions: Collection of PF via laparoscopy. Main Outcome Measures: Determination of PF concentrations ofMCP-1 by an ELISA and evaluation of its monocyte chemotactic activityusing a human hystiocytic cell line (U937). Results: The concentration of MCP-1 (median, range of values) was increased in the PF of endometriosis patients (283, 0 to 1,930 pg/mL; conversion factor to SI unit,0.115) compared with the control group (140, 0 to 435 pg/mL). The most significant elevation of MCP-1 levels was found in the stage II of the disease (371, 200 to 1,930 pg/mL). An increased chemotactic activity for monocytes (mean number of migrating cells/mm(2) +/- SD) also wasfound in stages I (1,460 +/- 312) and II (1,541 +/- 336) of the disease when compared with fertile controls (393 +/- 56). Forty percent to 53% of this activity was inhibited in the presence of an antibody specific to MCP-1. Conclusions: These observations are consistent with previous data indicating increased leukocyte chemotaxis in the PF of patients with endometriosis and suggest that MCP-1 may play a relevant role in the peritoneal inflammatory reaction associated with the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:46:02