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Titolo:
ENDOTOXEMIA AND COMPLEMENT ACTIVATION AFTER SEVERE BURN INJURIES - EFFECTS ON LEUKOCYTES, SOLUBLE SELECTINS, AND INFLAMMATORY CYTOKINES
Autore:
LJUNGHUSEN O; LUNDAHL J; NETTELBLAD H; NILSSON B; SJOGREN F; STENDAHL O;
Indirizzi:
KAROLINSKA HOSP,DEPT CLIN IMMUNOL S-17176 STOCKHOLM SWEDEN LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT MED MICROBIOL & IMMUNOL S-58185LINKOPING SWEDEN UNIV UPPSALA HOSP,DEPT CLIN IMMUNOL & TRANSFUS MED S-75185 UPPSALA SWEDEN
Titolo Testata:
Inflammation
fascicolo: 3, volume: 20, anno: 1996,
pagine: 229 - 241
SICI:
0360-3997(1996)20:3<229:EACAAS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN-ENDOTHELIAL CELLS; CHEMOTACTIC FACTORS; BACTERIAL LIPOPOLYSACCHARIDE; INCREASED EXPRESSION; ADHESION MOLECULE; BINDING-PROTEIN; MAC-1; RECEPTOR; INTERLEUKIN-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
O. Ljunghusen et al., "ENDOTOXEMIA AND COMPLEMENT ACTIVATION AFTER SEVERE BURN INJURIES - EFFECTS ON LEUKOCYTES, SOLUBLE SELECTINS, AND INFLAMMATORY CYTOKINES", Inflammation, 20(3), 1996, pp. 229-241

Abstract

In this study we followed the development of an inflammatory responsein a group of patients the first week after a burn in July. We detected elevated plasma endotoxin levels, on at least one occasion, in 6 of8 patients. No endotoxin was detected in the two patients with the lowest total burned surface area (less than or equal to 30%). We found evidence of complement activation as increased C3a levels, in parallel with a production of inflammatory cytokines (TNF-alpha, IL-6). The TNF-alpha levels increased significantly during the observation period, while the IL-6 levels were elevated already at admission, and remained so. Elevated levels of soluble E-selectin were detected, indicating endothelial cell activation. Despite the inflammatory response and a loss of inflammatory cells during the first days of the monitoring period, we found no evidence of cellular activation measured as increased expression of beta 2 integrin CD11b, nor increased plasma levels of soluble L-selectin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:52:40