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Titolo:
MOLECULAR ANALYSIS OF GLOMERULAR-DISEASES IN RENAL BIOPSIES - INITIALRESULTS OF A COLLABORATIVE INTERNATIONAL STUDY
Autore:
ESPOSITO C; STRIKER LJ; PATEL A; PETEN E; LIU ZH; SAKAI H; STRIKER GE; YANG CW; HIRSHMANN G; SCHENA P; GESUALDO T; FELD L; WAZ W; HUANG CC; LAI PC; HUANG JY; LEWIS E; ORLOWSKI J; KOIDE H; HORIKOSHI S; DAMICO G; FORNASIERI A; DIMARIO U; FUIANO G; LI L; FENG Z; JACOBS C; BEAUFILS H; JOUANNEAU C; BAUMELOU A; ARAKAWA M; NISHI S; UENO M; SRAER JD; MIGNON F; RONCO P; MOUGENOT B; RONDEAU E; PERALDI MN; DELARUE F; YAGAME M; SUZUKI D; DESTRIHOU CV; PIRSON Y; COSYNS JP; GARBAR C; JACOBSON H; FOGO A; CHEVALIER R; NORWOOD VF; THORNHILL B; EMANCIPATOR S; RAO C; ADLER S; BEAUMONT PM; HIRSCHBERG R; NAST C; COHEN A; MOORE J; CAROME MA; SRINSKY JJ;
Indirizzi:
NIDDK,RENAL CELL BIOL SECT,NIH,BLDG 10,ROOM 3N106,10 CTR DR MSC 1268 BETHESDA MD 20892 NIDDK,RENAL CELL BIOL SECT,NIH BETHESDA MD 20892 TOKAI UNIV,SCH MED,DEPT INTERNAL MED,DIV NEPHROL & METAB ISEHARA KANAGAWA 25911 JAPAN
Titolo Testata:
Proceedings of the Association of American Physicians
fascicolo: 3, volume: 108, anno: 1996,
pagine: 209 - 217
SICI:
1081-650X(1996)108:3<209:MAOGIR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE COLLAGEN; DIFFERENTIAL EXPRESSION; DIABETIC NEPHROPATHY; IV COLLAGEN; CELL;
Keywords:
KIDNEY GLOMERULUS; COLLAGEN; GENE EXPRESSION; GLOMERULONEPHRITIS; MEMBRANOUS; GLOMERULOSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
C. Esposito et al., "MOLECULAR ANALYSIS OF GLOMERULAR-DISEASES IN RENAL BIOPSIES - INITIALRESULTS OF A COLLABORATIVE INTERNATIONAL STUDY", Proceedings of the Association of American Physicians, 108(3), 1996, pp. 209-217

Abstract

An accurate assessment of which patient with glomerular disease will progress to end-stage renal failure would be an important addition to establishing prognosis and evaluating therapeutic strategies, We previously found the development of glomerular scarring in animal models was preceded by an increase in glomerular type IV collagen mRNAs and that the level of scarring predicted the rate of progression. The purposeof this study was to determine whether these findings apply to human glomerular diseases using microdissected glomeruli and assessment of mRNA by competitive PCR. After showing that the levels of type IV collagen mRNAs were elevated in sclerotic glomeruli isolated from nephrectomies, we undertook this preliminary cross-sectional study of type IV collagen subchain mRNAs in renal biopsies in two of the leading causes of glomerulosclerosis, diabetic nephropathy, and membranous glomerulopathy. We found that glomerular type IV collagen mRNA levels were altered in disease-specific ways. The relative levels of the individual alpha-chains of type IV collagen depended on the anatomic site of the glomerular lesions, The alpha 2 type IV/alpha 3 type IV collagen mRNA ratio was high in diabetes mellitus, but not in membranous glomerulopathy. These data, coupled with those obtained from experimental animals, suggest that a dysregulation of basement collagen synthesis underlies progressive glomerular scarring. If these conclusions are verified in prospective studies it will be feasible to assess the risk of developing progressive glomerulosclerosis in the individual patient and to quantitatively assess therapeutic responses in a timely manner.

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Documento generato il 13/07/20 alle ore 03:52:43