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Titolo:
PROSTAGLANDIN E(1) REDUCES THE GLOMERULAR MESSENGER-RNA EXPRESSION OFMONOCYTE-CHEMOATTRACTANT PROTEIN-1 IN ANTI-THYMOCYTE ANTIBODY-INDUCEDGLOMERULAR INJURY
Autore:
JOCKS T; ZAHNER G; FREUDENBERG J; WOLF G; THAISS F; HELMCHEN U; STAHL RAK;
Indirizzi:
UNIV HAMBURG,KRANKENHAUS EPPENDORF,MED KLIN,ABT NEPHROL OSTEOL,MARTINISTR 52 D-20246 HAMBURG GERMANY UNIV HAMBURG,DEPT MED,DIV NEPHROL HAMBURG GERMANY UNIV HAMBURG,DEPT PATHOL HAMBURG GERMANY
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 6, volume: 7, anno: 1996,
pagine: 897 - 905
SICI:
1046-6673(1996)7:6<897:PERTGM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HUMAN MESANGIAL CELLS; NECROSIS-FACTOR-ALPHA; CHEMOTACTIC PEPTIDE-1; GENE-EXPRESSION; FACTOR-I; GLOMERULONEPHRITIS; INTERLEUKIN-6; SUPPRESSION; ADHESION;
Keywords:
MONOCYTE-CHEMOATTRACTANT PROTEIN-1; PROSTAGLANDIN E(1); ANTI-THYMOCYTE ANTIBODY-INDUCED GLOMERULONEPHRITIS; MONOCYTES; ISOLATED PERFUSED RAT KIDNEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T. Jocks et al., "PROSTAGLANDIN E(1) REDUCES THE GLOMERULAR MESSENGER-RNA EXPRESSION OFMONOCYTE-CHEMOATTRACTANT PROTEIN-1 IN ANTI-THYMOCYTE ANTIBODY-INDUCEDGLOMERULAR INJURY", Journal of the American Society of Nephrology, 7(6), 1996, pp. 897-905

Abstract

To study whether prostaglandins (PG) can regulate the mRNA expressionof monocyte-chemoattractant protein 1 (MCP-1) in glomerular immune injury, MCP-1 mRNA levels were evaluated in anti-thymocyte antibody (ATS)-induced glomerular injury by Northern blotting and reverse transcription-polymerase chain reaction, Immune injury was induced in vivo by the intravenous application of ATS to male Wistar rats and in vitro by the perfusion of isolated rat kidneys with ATS and rat serum. In vivo 3 h and 5 days after antibody application, glomerular mRNA expression of MCP-1 was markedly enhanced compared with controls. In the isolatedperfused kidney, antibody and complement also induced an increase in MCP-1 expression at 10 min and 60 min after antibody perfusion. When the rats were treated with PGE (250 mu g, twice daily), the increase inMCP-1 expression was reduced. This was associated with a reduction ofintraglomerular recruitment of monocytes/macrophages, In the isolatedperfused kidneys, PGE(1) (1 mg/L) prevented the antibody- and rat serum-stimulated increase in glomerular MCP-1 mRNA expression. These datademonstrate that PGE(1) reduces glomerular MCP-1 mRNA expression in glomerulonephritis and in the isolated perfused rat kidney after induction of immune injury with antibody and complement. The data suggest that prostaglandins might mediate MCP-1 effects in glomerular immune injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:17:09