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Titolo:
DISTRIBUTIONS OF 2 HOMOLOGOUS SYNAPTIC VESICLE PROTEINS, SYNAPTOPORINAND SYNAPTOPHYSIN, IN THE MAMMALIAN RETINA
Autore:
BRANDSTATTER JH; LOHRKE S; MORGANS CW; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH,NEUROCHEM ABT D-60528 FRANKFURT GERMANY
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 370, anno: 1996,
pagine: 1 - 10
SICI:
0021-9967(1996)370:1<1:DO2HSV>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; INNER PLEXIFORM LAYER; CALCIUM-BINDING PROTEIN; DIFFERENTIAL EXPRESSION; MEMBRANE-PROTEIN; VERTEBRATE RETINA; HORIZONTAL CELLS; CHANNEL PROTEIN; AMACRINE CELL; BIPOLAR CELLS;
Keywords:
RIBBON SYNAPSES; CONVENTIONAL SYNAPSES; RAT RETINA; RABBIT RETINA; AMACRINE CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Brandstatter et al., "DISTRIBUTIONS OF 2 HOMOLOGOUS SYNAPTIC VESICLE PROTEINS, SYNAPTOPORINAND SYNAPTOPHYSIN, IN THE MAMMALIAN RETINA", Journal of comparative neurology, 370(1), 1996, pp. 1-10

Abstract

Synaptophysin and synaptoporin are homologous proteins that are amongthe most abundant synaptic vesicle proteins. Despite their high degree of sequence similarity, they are differentially distributed in the brain. The distribution of synaptophysin and synaptoporin was examined in the adult rat and rabbit retina by using single- and double-labeling immunocytochemistry with conventional light microscopy and confocal laser scanning microscopy. In the rat retina, synaptophysin immunoreactivity was found in the outer plexiform layer in terminals of photoreceptors and was homogeneously distributed throughout the inner plexiform layer. Synaptoporin immunoreactivity, however, was restricted to theinner plexiform layer. Labeling was most prominent in three distinct bands of the inner plexiform layer separated by two bands of very low synaptoporin immunoreactivity. In the rabbit retina, synaptophysin andsynaptoporin immunoreactivity were found in the inner and outer plexiform layers. In the inner plexiform layer, labeling for both vesicle proteins was homogeneous, with no detectable stratification. In the outer plexiform layer, synaptophysin was present in photoreceptor terminals, and synaptoporin was present in horizontal cells. Staining of isolated rabbit retinal cells confirmed that both the axonless A type and the axon-bearing B type horizontal cells are immunoreactive for synaptoporin. In addition, electron microscopy of synaptoporin-immunostainedrabbit retinas revealed no labeling of photoreceptor terminals but ofputative synaptic sites in horizontal cells in the outer plexiform layer. No functional correlation was found in the expression of either synaptic vesicle protein with the type of neuron or synapse (ribbon or conventional). (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:29:41