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Titolo:
LUNG CANCER-INDUCED BLINDNESS
Autore:
THIRKILL CE;
Indirizzi:
UNIV CALIF DAVIS,1603 ALHAMBRA BLVD SACRAMENTO CA 95816
Titolo Testata:
Lung cancer
fascicolo: 2-3, volume: 14, anno: 1996,
pagine: 253 - 264
SICI:
0169-5002(1996)14:2-3<253:LCB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOPLASTIC CEREBELLAR DEGENERATION; SMALL-CELL-CARCINOMA; MYASTHENIC SYNDROME; PHOTORECEPTOR DEGENERATION; PARANEOPLASTIC RETINOPATHY; AUTOIMMUNE BASIS; PURKINJE-CELLS; ANTIBODIES; AUTOANTIBODIES; EXPRESSION;
Keywords:
LUNG CANCER; CANCER-INDUCED AUTOIMMUNITY; RETINA; OPTIC NERVE; BRAIN; HYPERSENSITIVITY; CNS DEGENERATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Thirkill, "LUNG CANCER-INDUCED BLINDNESS", Lung cancer, 14(2-3), 1996, pp. 253-264

Abstract

Early investigations into the pathogenesis of vision loss in cancer patients noted the higher incidence with small cell carcinoma of the lung (SCCL), a neoplasia with suspected neuroendocrine origins [2-5,12,20,25,56,63,64]. The cause and effect relationship between the cancer and retinal deterioration was recognized, but the processes involved were not understood. Research eventually identified a sub-group of paraneoplastic retinopathy patients who exhibited indications of retinal hypersensitivity through their production of autoantibodies reactive with a single photoreceptor protein. The discovery of a small cell lung cancer culture actively expressing this same retinal autoantigen, provided tangible evidence to define a molecular basis for at least one type of paraneoplastic retinopathy. The identification of this immunologic anomaly illustrates how blindness can occur in some cancer patients,through the serendipitous initiation of ocular hypersensitivity, withvision loss developing as a cancer-induced autoimmune retinopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:01:16