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Titolo:
PEPTIDE AMIDATING ACTIVITY IN HUMAN BRONCHOALVEOLAR LAVAGE FLUID
Autore:
SCOTT FM; TRESTON AM; SHAW GL; AVIS I; SORENSON J; KELLY K; DEMPSEY EC; CANTOR AB; TOCKMAN M; MULSHINE JL;
Indirizzi:
BIOMARKERS & PREVENT RES BRANCH,SUITE 300,9610 MED CTR DR ROCKVILLE MD 20850 BIOMARKERS & PREVENT RES BRANCH ROCKVILLE MD 20850 UNIV COLORADO,HLTH SCI CTR,CTR CANC DENVER CO 80262 UNIV S FLORIDA,H LEE MOFFIT CANC CTR & RES INST TAMPA FL 33612 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH BALTIMORE MD 21205
Titolo Testata:
Lung cancer
fascicolo: 2-3, volume: 14, anno: 1996,
pagine: 239 - 251
SICI:
0169-5002(1996)14:2-3<239:PAAIHB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE NEUROINTERMEDIATE PITUITARY; BOMBESIN-LIKE PEPTIDES; LUNG-CANCER; ALPHA-AMIDATION; GROWTH-FACTORS; MONOOXYGENASE; ENZYME; CELLS; EXPRESSION; PURIFICATION;
Keywords:
PREVENTION; BIOMARKERS; TRANSLATIONAL RESEARCH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
F.M. Scott et al., "PEPTIDE AMIDATING ACTIVITY IN HUMAN BRONCHOALVEOLAR LAVAGE FLUID", Lung cancer, 14(2-3), 1996, pp. 239-251

Abstract

Monitoring respiratory epithelial biology may reveal individuals withincipient lung cancer. The expression of neuroendocrine (NE) markers in pulmonary epithelium is thought to be central to lung development, repair of injury and may contribute to carcinogenesis, In this study, we evaluate several candidate NE markers to determine the feasibility of prospective analysis of clinical specimens. The potential NE markers include the enzyme L-DOPA decarboxylase (DDC), the neuropeptide gastrin releasing peptide (GRP), and peptidyl-glycine alpha-amidating monooxygenase (PAM), the bifunctional enzyme responsible for the final bioactivation step of many neuropeptides. A comparison of PAM activity and DDC levels in 30 lung cancer cell lines indicated that peptide amidating activity may be an indicator of NE status. Bronchoalveolar lavage(BAL) fluid from subjects al risk of developing second primary lung cancer and from volunteers was obtained. The activity of the first PAM enzyme, peptidylglycine alpha-hydroxylating monooxygenase (PHM), ranged from not delectable to 507 pmol/h/mg protein in 57 specimens. The second PAM enzyme, peptidylamidoglycolate lyase (PAL), ranged from not detectable to 414 pmol/h/mg protein in 56 specimens. Using cluster analysis by the average linkage method, a group of enzyme values with PHM greater than 230 pmol/h/mg protein was determined. Long-term follow-upof these patients for new second primary lung cancers may help to determine the potential predictive value of PAM detected in the BAL fluid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:30:24