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Titolo:
THE EXTRANEURONAL TRANSPORTER FOR MONOAMINE TRANSMITTERS EXISTS IN CELLS DERIVED FROM HUMAN CENTRAL-NERVOUS-SYSTEM GLIA
Autore:
RUSS H; STAUDT K; MARTEL F; GLIESE M; SCHOMIG E;
Indirizzi:
UNIV HEIDELBERG,DEPT PHARMACOL,NEUENHEIMER FELD 366 D-69120 HEIDELBERG GERMANY UNIV HEIDELBERG,DEPT PHARMACOL D-69120 HEIDELBERG GERMANY
Titolo Testata:
European journal of neuroscience
fascicolo: 6, volume: 8, anno: 1996,
pagine: 1256 - 1264
SICI:
0953-816X(1996)8:6<1256:TETFMT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY ASTROGLIAL CULTURES; PRIMARY ASTROCYTE CULTURES; NORADRENALINE TRANSPORT; CATECHOLAMINE UPTAKE; BRAIN-REGIONS; AMINO-ACID; RAT-HEART; INHIBITION; OXIDASE; GLUTAMATE;
Keywords:
HUMAN GLIA; MPTP TOXICITY; NORADRENALINE; NOREPINEPHRINE; CATECHOLAMINES; UPTAKE(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
H. Russ et al., "THE EXTRANEURONAL TRANSPORTER FOR MONOAMINE TRANSMITTERS EXISTS IN CELLS DERIVED FROM HUMAN CENTRAL-NERVOUS-SYSTEM GLIA", European journal of neuroscience, 8(6), 1996, pp. 1256-1264

Abstract

From studies on sympathetically innervated peripheral tissues it is well known that both neuronal and nonneuronal transport systems contribute to the inactivation of released monoamine transmitters. The close proximity between synapses and glia cell processes in the CNS leads tothe so far unresolved question whether non-neuronal transporters are involved in the inactivation of centrally released monoamine transmitters such as noradrenaline, dopamine and 5-hydroxytryptamine. 1-Methyl-4-phenylpyridinium (MPP(+)) is a prototypical substrate of the extraneuronal monoamine transporter (uptake(2)). [H-3]MPP(+) was found to accumulate in various human glioma cell lines. [H-3]MPP(+) transport was characterized in more detail in HTZ146 human glioma cells. The K-i values of various compounds for the inhibition of initial rates of [H-3]MPP(+) transport into HTZ146 cells were closely correlated with the known K-i values for the inhibition of the extraneuronal monoamine transporter (P < 0.001, r = 0.991, n = 7). The rank order of inhibitory potencies was decynium 22 > corticosterone > cyanine 863 > O-methylisoprenaline > quinine > clonidine > quinidine. [H-3]MPP(+) accumulation was investigated not only in various CNS tumour cell lines but also in primary cultures of human astrocytes and rat cerebral cortex slices. In all tested experimental systems, accumulation was sensitive to cyanine-related inhibitors of the extraneuronal monoamine transporter. These findings suggest that the extraneuronal monoamine transporter exists inglia cells. Furthermore, it was shown that MPP(+) is able to make useof the extraneuronal monoamine transporter not only to enter but alsoto leave glia cells, This finding suggests that the extraneuronal monoamine transporter may play a key role in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:00:42