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Titolo:
CORTISOL REGULATION IN POSTTRAUMATIC-STRESS-DISORDER AND MAJOR DEPRESSION - A CHRONOBIOLOGICAL ANALYSIS
Autore:
YEHUDA R; TEICHER MH; TRESTMAN RL; LEVENGOOD RA; SIEVER LJ;
Indirizzi:
BRONX VET AFFAIRS,116-A,130 W KNIGHTSBRIDGE RD BRONX NY 10468 MT SINAI SCH MED,DEPT PSYCHIAT,POST TRAMAT STRESS DISORDER PROGRAM BRONX NY 10468 MT SINAI SCH MED,DEPT PSYCHIAT,MOOD & PERSONAL DISORDER PROGRAM BRONXNY 10468 MCLEAN HOSP,DEV BIOPSYCHIAT & CLIN CHRONOBIOL PROGRAM BOSTON MA 00000 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02115
Titolo Testata:
Biological psychiatry
fascicolo: 2, volume: 40, anno: 1996,
pagine: 79 - 88
SICI:
0006-3223(1996)40:2<79:CRIPAM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RECEPTOR NUMBER; ENDOGENOUS-DEPRESSION; LOCOMOTOR-ACTIVITY; SUPPRESSION; SECRETION; ADRENOCORTICOTROPIN; DYSREGULATION; NEUROBIOLOGY; ADOLESCENTS; RHYTHMS;
Keywords:
POSTTRAUMATIC STRESS DISORDER; MAJOR DEPRESSIVE DISORDER; CORTISOL; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; CIRCADIAN RHYTHM; SENSITIZATION; BIOLOGICAL CLOCKS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R. Yehuda et al., "CORTISOL REGULATION IN POSTTRAUMATIC-STRESS-DISORDER AND MAJOR DEPRESSION - A CHRONOBIOLOGICAL ANALYSIS", Biological psychiatry, 40(2), 1996, pp. 79-88

Abstract

The aim of the present study was to evaluate the pattern of basal cortisol release in PTSD and major depression using a chronobiological analysis. Plasma for cortisol determination was obtained from 15 combat veterans with PTSD, 14 subjects with major depression, and 15 normal men every 30 min during a 24-hour period of bed rest. Raw cortisol datawere modeled using standard and multioscillator cosinor models to determine the best fitting functions for circadian, hemicircadian, and ultradian components of cortisol release. PTSD subjects had substantially lower cortisol levels, and displayed a pattern of cortisol release that was better modeled by circadian rhythm. PTSD subjects also showed a greater circadian signal-to-noise ratio than the other groups. In contrast depressed patients displayed a less rhythmic, more chaotic pattern of cortisol release. The pattern of cortisol secretion and regulation observed in the PTSD group under baseline conditions may reflect an exaggerated sensitization, whereas the chronobiological alterations in depression may reflect dysregulation, of the hypothalamic-pituitary-adrenal (HPA) axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 15:33:53