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Titolo:
STEREOSELECTIVE DETERMINATION OF FLUOXETINE AND NORFLUOXETINE ENANTIOMERS IN PLASMA SAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
Autore:
PICHINI S; PACIFICI R; ALTIERI I; PELLEGRINI M; ZUCCARO P;
Indirizzi:
IST SUPER SANITA,DEPT CLIN BIOCHEM,VIALE REGINA ELENA 299 I-00161 ROME ITALY
Titolo Testata:
Journal of liquid chromatography & related technologies
fascicolo: 12, volume: 19, anno: 1996,
pagine: 1927 - 1935
SICI:
1082-6076(1996)19:12<1927:SDOFAN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-CAPTURE DETECTION; SEROTONIN-UPTAKE INHIBITOR; GAS-CHROMATOGRAPHY; OPTICAL ISOMERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
S. Pichini et al., "STEREOSELECTIVE DETERMINATION OF FLUOXETINE AND NORFLUOXETINE ENANTIOMERS IN PLASMA SAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY", Journal of liquid chromatography & related technologies, 19(12), 1996, pp. 1927-1935

Abstract

The simultaneous liquid chromatographic determination of the enantiomers of both fluoxetine and its metabolite norfluoxetine in plasma samples of treated patients is described. The compounds are subjected to solid phase extraction before chromatography. The separation of the analytes is achieved using two chiralcel ODR columns on-line coupled and a mobile phase consisting of acetonitrile-NaClO4 0.3M (66/34 v/v, pH 2.5) at a flow rate of 0.6 mL/min. The compounds were detected by ultraviolet absorbance at 220 nm. The limit of quantification for each compound was 10 ng/mL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:54:23