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Titolo:
AIDS DEMENTIA COMPLEX - INCIDENCE, CLINICAL PROFILE AND IMPACT OF ZIDOVUDINE TREATMENT
Autore:
SANCHEZPORTOCARRERO J; JIMENEZESCRIG A; PEREZCECILIA E; AYUSOMATEOS JL; ROCA V; YAGUE MR; BARQUERO M; RAMIREZ C; DESEIJAS EV;
Indirizzi:
HOSP UNIV SAN CARLOS,SERV NEUROL,DEPT NEUROL,MARTIN LAGOS S-N E-28040MADRID SPAIN HOSP UNIV SAN CARLOS,HIV UNIT E-28040 MADRID SPAIN HOSP UNIV SAN CARLOS,DEPT INTERNAL MED E-28040 MADRID SPAIN HOSP RAMON Y CAJAL,DEPT NEUROL E-28034 MADRID SPAIN UNIV CANTABRIA,DEPT MED & PSYCHIAT CANTABRIA SPAIN
Titolo Testata:
European journal of neurology
fascicolo: 3, volume: 3, anno: 1996,
pagine: 191 - 197
SICI:
1351-5101(1996)3:3<191:ADC-IC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CEREBROSPINAL-FLUID BETA-2-MICROGLOBULIN; NERVOUS-SYSTEM INVOLVEMENT; IMMUNE-DEFICIENCY SYNDROME; HIV-INFECTION; NEUROLOGICAL COMPLICATIONS; BRAIN; MANIFESTATIONS; MORTALITY; THERAPY;
Keywords:
HUMAN IMMUNODEFICIENCY VIRUS; AIDS; AIDS DEMENTIA COMPLEX; ZIDOVUDINE; BETA-2-MICROGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Sanchezportocarrero et al., "AIDS DEMENTIA COMPLEX - INCIDENCE, CLINICAL PROFILE AND IMPACT OF ZIDOVUDINE TREATMENT", European journal of neurology, 3(3), 1996, pp. 191-197

Abstract

This study aimed to determine the incidence of AIDS dementia complex (ADC), the clinical data which distinguish it from other neurological complications of HIV infection, and the impact of zidovudine (AZT) therapy on the appearance and course of this condition, Data on the neurological complications of HIV patients treated at a community hospital from 1988 to 1992 were collected prospectively, Out of 500 AIDS patients treated at the hospital, there were 142 patients with neurological complications, with an average of 1.42 complications/patient. There were 23 patients diagnosed as having ADC; with an estimated incidence of4.6%, it was the most frequent neurological complication, after cerebral toxoplasmosis, Age was higher in patients with ADC as first manifestation of AIDS with respect to ADC patients with previous AIDS diagnosed, Compared with the group of patients suffering from other neurological complications, patients with ADC showed significant differences in several biological markers of progression to AIDS, such as hemoglobin, hematocrit, global lymphocyte count, serum beta(2)-microglobulin and serum IgA, CD4 count was similar in both groups, Ten ADC patients had been treated previously with AZT. Dementia continued progressing in seven of these patients and remained stable in three, Of the other 13 cases not treated previously with the drug, eight received AZT therapy, and a favourable response was obtained in three patients (p = 0.068), ADC represents a major neurological complication in AIDS patients, AZT therapy may delay the appearance of ADC, but not prevent it, A trend towards a favourable response to AZT was observed in ADC patients who had not been treated with it previously.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:21:33