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Titolo:
TRANSFORMING GROWTH-FACTOR-ALPHA, EPIDERMAL GROWTH-FACTOR, AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN TESTIS OBTAINED FROM BIOPSY AND CASTRATION - IMMUNOHISTOCHEMICAL STUDY
Autore:
NAKAZUMI H; SASANO H; MAEHARA I; ORIKASA S;
Indirizzi:
SHIRAKAWA KOUSEI HOSP,DEPT UROL,114 YOKOMACHI SHIRAKAWA FUKUSHIMA 961JAPAN TOHOKU UNIV,SCH MED,DEPT PATHOL SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT UROL SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Tohoku Journal of Experimental Medicine
fascicolo: 4, volume: 178, anno: 1996,
pagine: 381 - 388
SICI:
0040-8727(1996)178:4<381:TGEGAE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-INTERACTIONS;
Keywords:
TESTIS; EGF; TGF-ALPHA; EGFR; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
H. Nakazumi et al., "TRANSFORMING GROWTH-FACTOR-ALPHA, EPIDERMAL GROWTH-FACTOR, AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN TESTIS OBTAINED FROM BIOPSY AND CASTRATION - IMMUNOHISTOCHEMICAL STUDY", Tohoku Journal of Experimental Medicine, 178(4), 1996, pp. 381-388

Abstract

We analyzed expression of transforming growth factor (TGF)-alpha, epidermal growth factor (EGF) and their receptor, EGF receptor (EGFR), byimmunohistochemistry in the human testis to determine the possible roles of these growth factors in human testicular function. Specimens were obtained from 17 patients including 9 patients with infertility, 4 patients with prostatic carcinoma and 4 patients with contralateral testicular tumor. EGF immunoreactivity was positive in the hyperplasic Leydig cells of one patient but negative in the other cases. On the other hand, strong TGF-alpha immunoreactivity was observed in Leydig cells, with weak staining in Sertoli cells and germ cells in cases with normal spermatogenesis. EGFR immunoreactivity was observed in the Leydigand peritubular cells, appearing as membrane staining. Marked immunoreactivity for TGF-alpha was observed in the Sertoli cells in testes with decreased spermatogenesis, especially in the Sertoli-cell-only syndrome. This finding may indicate a compensatory increase of TGF-alpha expression in the Sertoli cells accompanying a decrease in spermatogenesis. No significant correlation was found between the degrees of spermatogenesis and immunolocalization of the EGF receptor. These findings suggestthat TGF-alpha is a locally produced growth factor that is involved in spermatogenesis in the human testis via an autocrine and/or paracrine mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:05:26