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Titolo:
INVOLVEMENT OF EICOSANOIDS AND INOSITOL 1,4,5-TRISPHOSPHATE IN SEROTONIN-INDUCED SECRETION IN RAT ILEUM IN-VIVO
Autore:
HANSEN MB; JAFFE BM;
Indirizzi:
SUNY HLTH SCI CTR,DEPT SURG,450 CLARKSON AVE BROOKLYN NY 11203
Titolo Testata:
FONTES ARTIS MUSICAE
fascicolo: 1, volume: 105, anno: 1993,
pagine: 77 - 82
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL ELECTROLYTE TRANSPORT; GUINEA-PIG ILEUM; DIARRHEAL DISEASE; ARACHIDONIC-ACID; CHOLERA-TOXIN; 5-HYDROXYTRYPTAMINE; CALCIUM; RECEPTORS; 5-HT3; WATER;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Hansen e B.M. Jaffe, "INVOLVEMENT OF EICOSANOIDS AND INOSITOL 1,4,5-TRISPHOSPHATE IN SEROTONIN-INDUCED SECRETION IN RAT ILEUM IN-VIVO", FON ART MUS, 105(1), 1993, pp. 77-82

Abstract

1. The possible involvement of eicosanoids, cyclic adenosine monophosphate (c-AMP), and inositol 1,4,5-trisphosphate (IP3) in serotonin-(5-hydroxytryptamine-) induced secretion in rat ileum in vivo was studied. 2. Serotonin caused a significant increase in mean IP3 levels. Indomethacin reduced serotonin-induced secretion of water by 28%. Thus, IP3and eicosanoids appear to be intracellular mediators of serotonin-induced secretion in rat ileum. 3. Serotonin, BRL 24924, and cisapride all inhibited theophylline-induced increases in c-AMP concentrations in rat ileal segments. Neither BRL 24924 nor cisapride caused any change in IP3 levels. 4. These data suggest that a 5-HT2 receptor dependent on IP3 and eicosanoids is involved in mediating in serotonin-induced secretion in rat small intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:23:29