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Titolo:
ALPHA-INTERFERON BUT NOT BETA-INTERFERON IS USEFUL IN CHRONIC ACTIVE HEPATITIS DUE TO HEPATITIS-C VIRUS - A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED STUDY
Autore:
VILLA E; TRANDE P; GROTTOLA A; BUTTAFOCO P; REBECCHI AM; STROFFOLINI T; CALLEA F; MERIGHI A; CAMELLINI L; ZOBOLI P; COSENZA R; MIGLIOLI L; LORIA P; IORI R; CARULLI N; MANENTI F;
Indirizzi:
UNIV MODENA,CHAIR GASTROENTEROL,VIA POZZO 71 I-41100 MODENA ITALY SPEDALI CIVIL BRESCIA,DEPT MORBID ANAT BRESCIA ITALY UNIV MODENA,INST INTERNAL MED I-41100 MODENA ITALY
Titolo Testata:
Digestive diseases and sciences
fascicolo: 6, volume: 41, anno: 1996,
pagine: 1241 - 1247
SICI:
0163-2116(1996)41:6<1241:ABNBIU>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
B CHRONIC HEPATITIS; CHRONIC NON-A; FIBROBLAST INTERFERON; RNA; SERUM; THERAPY; GENOMES; CANCER;
Keywords:
CHRONIC HEPATITIS C; HCV GENOTYPE; INTERFERON-ALPHA; INTERFERON-BETA; RANDOMIZED CONTROLLED TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
E. Villa et al., "ALPHA-INTERFERON BUT NOT BETA-INTERFERON IS USEFUL IN CHRONIC ACTIVE HEPATITIS DUE TO HEPATITIS-C VIRUS - A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED STUDY", Digestive diseases and sciences, 41(6), 1996, pp. 1241-1247

Abstract

Interferon-alpha has been widely used in chronic hepatitis C, but controlled studies with intramuscular interferon-beta are lacking. We therefore performed a prospective, double-blind, randomized study comparing intramuscular IFN-alpha and -beta in patients with chronic hepatitis C. Sixty patients were randomly assigned to receive 3 MU thrice weekly intramuscularly of either recombinant IFN-alpha or leukocyte IFN-alpha or fibroblast IFN-beta for six months. Nine of 20 patients (45.0%)in the recombinant IFN, 5/19 (26.3%) in the leukocyte IFN, and none in the IFN-beta group had a complete response during therapy (recombinant IFN vs IFN-beta: P < 0.01). Only in IFN-alpha-treated patients, wasinfection with a single HCV genotype (type 2a or 2b) associated with significantly better long-term outcome. IFN-alpha is useful in chronichepatitis C while intramuscular IFN-beta interferon does not exert any beneficial effect. This is probably due to an insufficient bioavailability of IFN-beta when given intramuscularly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:53:03