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Titolo:
EFFECT OF CLOZAPINE ON MOTOR FUNCTION IN SCHIZOPHRENIC-PATIENTS
Autore:
VRTUNSKI PB; KONICKI PE; KWON KY; JASKIW GJ; JASKIW GE;
Indirizzi:
CLEVELAND VET AFFAIRS MED CTR,PSYCHIAT SERV 116A,1000 BUCKSVILLE RD BRECKSVILLE OH 44141 CASE WESTERN RESERVE UNIV,SCH MED BRECKSVILLE OH 44141
Titolo Testata:
Schizophrenia research
fascicolo: 1-2, volume: 20, anno: 1996,
pagine: 187 - 198
SICI:
0920-9964(1996)20:1-2<187:EOCOMF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLOGICAL SOFT SIGNS; TARDIVE-DYSKINESIA; CLINICAL-SIGNIFICANCE; VENTRICULAR SIZE; SEIZURES; NEUROLEPTICS; DYSFUNCTION; VARIABILITY; ENLARGEMENT; SYMPTOMS;
Keywords:
SCHIZOPHRENIA; MOTOR FUNCTION IMPAIRMENT; FORCE CONTROL; ATYPICAL ANTIPSYCHOTIC DRUG; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
P.B. Vrtunski et al., "EFFECT OF CLOZAPINE ON MOTOR FUNCTION IN SCHIZOPHRENIC-PATIENTS", Schizophrenia research, 20(1-2), 1996, pp. 187-198

Abstract

It is well established that clozapine is less likely than typical antipsychotic drugs to cause clinically discernible extrapyramidal side-effects. There is a paucity of data, however, on clozapine's motor effects. In this report we compare normal controls to groups of chronic schizophrenic patients treated with either typical antipsychotic drugs or with clozapine. Motor function was measured with a target-matching task, a test relying on submaximal sustained force control. Results indicated that patients on clozapine performed with significantly lower accuracy (greater variability) of force control. Even though the clozapine patients were treatment resistant to typical antipsychotic drugs, and many had a history of tardive dyskinesia, we postulate that the observed deficit is likely due to clozapine treatment rather than to earlier treatments or other factors. The observed force control deficit may be the result of an increase in myoclonus and a generally lower level of overall motor activity.

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Documento generato il 05/04/20 alle ore 12:17:13