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Titolo:
LATENT INHIBITION IN SCHIZOPHRENIA
Autore:
SWERDLOW NR; BRAFF DL; HARTSTON H; PERRY W; GEYER MA;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT PSYCHIAT LA JOLLA CA 92093
Titolo Testata:
Schizophrenia research
fascicolo: 1-2, volume: 20, anno: 1996,
pagine: 91 - 103
SICI:
0920-9964(1996)20:1-2<91:LIIS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED SUPPRESSION PARADIGM; ATTENTION DISORDER; STARTLE REFLEX; D-AMPHETAMINE; RATS ABILITY; HALOPERIDOL; DOPAMINE; FACILITATION; HYPOTHESIS; DISRUPTION;
Keywords:
COGNITION; LATENT INHIBITION; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
N.R. Swerdlow et al., "LATENT INHIBITION IN SCHIZOPHRENIA", Schizophrenia research, 20(1-2), 1996, pp. 91-103

Abstract

Latent inhibition (LI) refers to the retarded acquisition of a conditioned response that occurs if the subject being tested is first preexposed to the to-be-conditioned stimulus (CS) without the paired unconditioned stimulus (UCS). Because the 'irrelevance' of the to-be-conditioned stimulus is established during non-contingent preexposure, the slowed acquisition of the CS-UCS association is thought to reflect the process of overcoming this learned irrelevance. Latent inhibition has been reported to be diminished in acutely hospitalized schizophrenia patients. If acutely hospitalized schizophrenia patients are preexposed to the CS, they learn the association as fast as, and perhaps faster than, patients who are not preexposed to the CS. This finding has been interpreted as reflecting the inability of acute schizophrenia patientsto ignore irrelevant stimuli. In this study, the LI paradigm was identical to the one used in previous reports of LI deficits in schizophrenia patients (Baruch et al., 1988). Latent inhibition was observed in normal control subjects (n=73), including individuals identified as 'psychosis-prone' based on established screening criteria, and in anxiety (n=19) and mood disorder (n=13) patients. Learning scores (trials tocriterion) in 'acutely' hospitalized as well as 'chronic' hospitalized schizophrenia patients (n=45) were significantly elevated in both preexposed and non-preexposed subjects, compared to controls. Acute schizophrenia patients exhibited intact LI. Separate cohorts of acute and chronic schizophrenia patients (n=23) and normal controls (n=34) exhibited intact LI when tested in a new, easier-to-acquire computerized LIparadigm. These results fail to identify specific LI deficits in schizophrenia patients, and raise the possibility that previously observedLI deficits in schizophrenia patients may reflect, at least in part, performance deficits related to learning acquisition.

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Documento generato il 10/04/20 alle ore 02:05:50