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Titolo:
A CONTROLLED CLINICAL-TRIAL OF DORZOLAMIDE - A SINGLE-CENTER SUBSET OF A MULTICENTER STUDY
Autore:
SIMPSON AJ; GRAY TB; BALLANTYNE C;
Indirizzi:
CHRISTCHURCH HOSP,DEPT OPHTHALMOL,PRIVATE BAG 4710 CHRISTCHURCH NEW ZEALAND
Titolo Testata:
Australian and New Zealand journal of ophthalmology
fascicolo: 1, volume: 24, anno: 1996,
pagine: 39 - 42
SICI:
0814-9763(1996)24:1<39:ACCOD->2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBONIC-ANHYDRASE INHIBITOR; EFFICACY;
Keywords:
DORZOLAMIDE; GLAUCOMA; OCULAR HYPERTENSION; TOPICAL CARBONIC ANHYDRASE INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
4
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Simpson et al., "A CONTROLLED CLINICAL-TRIAL OF DORZOLAMIDE - A SINGLE-CENTER SUBSET OF A MULTICENTER STUDY", Australian and New Zealand journal of ophthalmology, 24(1), 1996, pp. 39-42

Abstract

Purpose: To assess the safety and intraocular pressure (IOP)-loweringactivity of 2% dorzolamide (topical carbonic anhydrase inhibitor), compared to 0.5% timolol and 0.5% betaxolol eyedrops. Methods: A parallel, masked, randomised one-year clinical trial was conducted in 16 patients with open-angle glaucoma or ocular hypertension, being a subset of a multicentre study which enrolled 523 subjects. Patients had IOP > 22 mmHg in one eye at baseline following washout of ocular hypotensivemedications and were then randomised in a 3:1:1 ratio to receive 2% dorzolamide thrice daily, 0.5% timolol twice daily or 0.5% betaxolol twice daily respectively. IOP was measured at Hour 2 (morning peak), Hour 5 and Hour 8 (afternoon trough for dorzolamide) at baseline, Weeks 2and 4 and Months 2, 3, 6, 9 and 12. Results: Topical dorzolamide 2% solution was well tolerated and safe. Mean IOP for dorzolamide at Hour 2 was 29.1 mmHg at baseline and 20.8 mmHg on treatment at one year, a 28.5% change. Mean IOP for dorzolamide at Hour 8 was 24.5 mmHg at baseline and 20.2 mmHg on treatment at one year, a 17.6% change. Comparable percent changes for timolol and betaxolol were 43.2/25.7 mmHg at Hour 2 and 21.9/13.5 mmHg at Hour 8 respectively. Conclusions: Dozolamide2% given thrice daily was well tolerated and safe, with a clinically significant effect on IOP comparable to betaxolol 0.5% twice daily, but not as great as timolol 0.5% twice daily.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:55:53