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OPAC HELP

Titolo:
A CRITICAL ROLE FOR TRANSFORMING GROWTH-FACTOR-BETA BUT NOT INTERLEUKIN-4 IN THE SUPPRESSION OF T-HELPER TYPE 1-MEDIATED COLITIS BY CD45RB(LOW) CD4(-CELLS() T)
Autore:
POWRIE F; CARLINO J; LEACH MW; MAUZE S; COFFMAN RL;
Indirizzi:
DNAX RES INST MOLEC & CELLULAR BIOL INC,901 CALIF AVE PALO ALTO CA 94304 DNAX RES INST MOLEC & CELLULAR BIOL INC PALO ALTO CA 94304 CELTRIX PHARMACEUT INC SANTA CLARA CA 95054 SCHERING PLOUGH CORP,RES INST LAFAYETTE NJ 07848
Titolo Testata:
The Journal of experimental medicine
fascicolo: 6, volume: 183, anno: 1996,
pagine: 2669 - 2674
SICI:
0022-1007(1996)183:6<2669:ACRFTG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCE WASTING DISEASE; IMMUNE-RESPONSES; MICE; CYTOKINES; SUBSET; INVIVO; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Powrie et al., "A CRITICAL ROLE FOR TRANSFORMING GROWTH-FACTOR-BETA BUT NOT INTERLEUKIN-4 IN THE SUPPRESSION OF T-HELPER TYPE 1-MEDIATED COLITIS BY CD45RB(LOW) CD4(-CELLS() T)", The Journal of experimental medicine, 183(6), 1996, pp. 2669-2674

Abstract

A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4(+) splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4(+) T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation or function of protective cells as CD45RB(low) CD4(+) cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4(+) cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:18:40