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Titolo:
CWR22 - THE FIRST HUMAN PROSTATE-CANCER XENOGRAFT WITH STRONGLY ANDROGEN-DEPENDENT RELAPSED STRAINS BOTH IN-VIVO AND IN SOFT AGAR
Autore:
NAGABHUSHAN M; MILLER CM; PRETLOW TP; GIACONIA JM; EDGEHOUSE NL; SCHWARTZ S; KUNG HJ; WHITE RWD; GUMERLOCK PH; RESNICK MI; AMINI SB; PRETLOW TG;
Indirizzi:
CASE WESTERN RESERVE UNIV,MED CTR,INST PATHOL,DEPT PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,INST PATHOL,DEPT PATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT GENET CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT MOLEC BIOL & MICROBIOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT EPIDEMIOL & BIOSTAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT UROL CLEVELAND OH 44106 UNIV CALIF DAVIS,MED CTR,DEPT UROL SACRAMENTO CA 95817 UNIV CALIF DAVIS,MED CTR,DEPT HEMATOL ONCOL SACRAMENTO CA 95817
Titolo Testata:
Cancer research
fascicolo: 13, volume: 56, anno: 1996,
pagine: 3042 - 3046
SICI:
0008-5472(1996)56:13<3042:C-TFHP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA; CELLS; ANTIGEN; LNCAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M. Nagabhushan et al., "CWR22 - THE FIRST HUMAN PROSTATE-CANCER XENOGRAFT WITH STRONGLY ANDROGEN-DEPENDENT RELAPSED STRAINS BOTH IN-VIVO AND IN SOFT AGAR", Cancer research, 56(13), 1996, pp. 3042-3046

Abstract

Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and relapse less than 5 weeks after androgen withdrawal. After androgen withdrawal, the human primary prostate cancer xenograft CWR22 regresses markedly, and prostate-specific antigen (PSA) falls up to 3000-fold in the blood of mice. PSA usually returns to normal. In some animals, the tumor relapses and is then designated CWR22R. In these animals, PSA starts to rise approximately 2-7 months, and tumor begins to grow 3-10 months after castration. Animals with CWR22 need to be euthanized because of large tumors 6-12 weeks after the transplantation of CWR22. Androgen withdrawal prolongs life approximately 3-4-fold.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:56:48