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Titolo:
FUNCTIONAL EXPRESSION AND CELLULAR MESSENGER-RNA LOCALIZATION OF A G-PROTEIN-ACTIVATED K-BRAIN( INWARD RECTIFIER ISOLATED FROM RAT)
Autore:
DISSMANN E; WISCHMEYER E; SPAUSCHUS A; VONPFEIL D; KARSCHIN C; KARSCHIN A;
Indirizzi:
MAX PLANCK INST BIOPHYS CHEM D-37077 GOTTINGEN GERMANY MAX PLANCK INST BIOPHYS CHEM D-37077 GOTTINGEN GERMANY MAX PLANCK INST EXPTL MED D-37077 GOTTINGEN GERMANY
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 223, anno: 1996,
pagine: 474 - 479
SICI:
0006-291X(1996)223:2<474:FEACML>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM CHANNEL; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
E. Dissmann et al., "FUNCTIONAL EXPRESSION AND CELLULAR MESSENGER-RNA LOCALIZATION OF A G-PROTEIN-ACTIVATED K-BRAIN( INWARD RECTIFIER ISOLATED FROM RAT)", Biochemical and biophysical research communications, 223(2), 1996, pp. 474-479

Abstract

We have cloned by homology screening from a rat brain cDNA library a GIRK3-type (Kir 3.3) inwardly rectifying K+ channel subunit with high structural similarity to other subfamily members whose activity is thought to be controlled by receptor-stimulated G proteins. when heterologously expressed both in Xenopus oocytes and in mammalian COS-7 cells,rbGIRK3 subunits individually fail to form functional channels. In contrast, when coexpressed with other GIRK subunits, rbGIRK3 gives rise to prominent currents which are enhanced by the stimulation of coexpressed 5-HT1A receptors. In-situ hybridizations show that of all GIRK subunits rbGIRK3 is most widely distributed and strongly expressed throughout the rat brain and thus may play an important role in central signal processing. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 14:46:36