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Titolo:
A REVIEW OF THE ASSOCIATION OF ESTROGENS AND PROGESTINS WITH CARDIOVASCULAR-DISEASE IN POSTMENOPAUSAL WOMEN
Autore:
PSATY BM; HECKBERT SR; ATKINS D; SISCOVICK DS; KOEPSELL TD; WAHL PW; LONGSTRETH WT; WEISS NS; WAGNER EH; PRENTICE R; FURBERG CD;
Indirizzi:
CARDIOVASC HLTH RES UNIT,METROPOLITAN PK 2 BLDG,SUITE 1360,1730 MINORAVE SEATTLE WA 98101 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 GRP HLTH COOPERAT PUGET SOUND,CTR HLTH STUDIES SEATTLE WA 00000 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103
Titolo Testata:
Archives of internal medicine
fascicolo: 12, volume: 153, anno: 1993,
pagine: 1421 - 1427
SICI:
0003-9926(1993)153:12<1421:AROTAO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; NON-CONTRACEPTIVE ESTROGENS; ORAL-CONTRACEPTIVES; MYOCARDIAL-INFARCTION; REPLACEMENT THERAPY; FOLLOW-UP; LIPOPROTEIN CHOLESTEROL; THROMBOEMBOLIC DISEASE; HORMONAL REPLACEMENT; CONJUGATED ESTROGENS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
B.M. Psaty et al., "A REVIEW OF THE ASSOCIATION OF ESTROGENS AND PROGESTINS WITH CARDIOVASCULAR-DISEASE IN POSTMENOPAUSAL WOMEN", Archives of internal medicine, 153(12), 1993, pp. 1421-1427

Abstract

The purpose of this article was to review, with special attention to the hypothesized mechanisms of atherosclerosis and thrombosis, the literature on the association of estrogens and progestins with cardiovascular disease. The data sources included recent reviews and their citations as well as literature searches of Medline. For coronary heart disease, we relied on a recent meta-analysis; for the lipid effects of estrogens and progestins, we refer to recent reviews and studies; for stroke, we identified all cohort and case-control studies; and for the effects of hormones on coagulation factors, we identified all relevant studies. The lipid effects of estrogens in postmenopausal women probably prevent atherosclerosis, and we would expect long duration o f use rather than current use to provide the greatest benefit. Few epidemiologic studies have, however, assessed duration of estrogen use. High doses of estrogens are likely to be thrombogenic during current use, andit is possible that even moderate doses may increase the risk of clotting among women who smoke or who have existing coronary atherosclerosis. Compared with the lipid effects of estrogens alone, the lipid effects of combined therapy with progestins may increase atherosclerosis. The effect of progestins on coagulation factors is largely unknown, and no epidemiologic study has assessed the risk of cardiovascular disease associated with the use of combined hormone therapy in postmenopausal women. Cardiovascular risk or benefit associated with the use of postmenopausal hormones may involve several competing mechanisms, including effects on prostaglandins and vascular tone as well as atherosclerosis and thrombosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:58:20