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Titolo:
RESPONSIVENESS OF THE GLUCOCORTICOID-SUPPRESSED PITUITARY-ADRENOCORTICAL SYSTEM OF PIGEONS (COLUMBA-LIVIA DOMESTICA) TO STIMULATION WITH ARGININE-VASOPRESSIN
Autore:
WESTERHOF I; VANDENBROM WE; MOL JA;
Indirizzi:
UNIV UTRECHT,FAC VET MED,SECT AVIAN & EXOT ANIM MED,DEPT CLIN SCI COMPANION ANIM,YALELAAN 8 3584 CM UTRECHT NETHERLANDS
Titolo Testata:
Avian diseases
fascicolo: 2, volume: 40, anno: 1996,
pagine: 312 - 320
SICI:
0005-2086(1996)40:2<312:ROTGP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; RECOVERY; DOGS; THERAPY; DEXAMETHASONE; RESPONSES; AXIS; RAT;
Keywords:
HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS; GLUCOCORTICOID; AVIAN; BIRD; DEXAMETHASONE; CORTISOL; PREDNISOLONE; DIURNAL RHYTHM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
I. Westerhof et al., "RESPONSIVENESS OF THE GLUCOCORTICOID-SUPPRESSED PITUITARY-ADRENOCORTICAL SYSTEM OF PIGEONS (COLUMBA-LIVIA DOMESTICA) TO STIMULATION WITH ARGININE-VASOPRESSIN", Avian diseases, 40(2), 1996, pp. 312-320

Abstract

This paper reports on the duration of the suppressive effects of single high and low doses of dexamethasone, cortisol, and prednisolone on the pituitary-adrenocortical (PA) system in pigeons. Tn addition, the effects of long-term daily administration of a high dose of dexamethasone are reported. In Expt. 1, low and high doses of dexamethasone (0.5mu g/kg and 0.5 mg/kg), cortisol (15 mu g/kg and 1.5 mg/kg), and prednisolone (3.5 mu g/kg and 3.5 mg/kg)were administered around tile expected nadir (4 hr before the peak) of the diurnal plasma corticosteroneconcentration. The recovery of the PA system was investigated by measuring plasma corticosterone concentrations before and 30 min after arginine vasopressin (AVP) stimulation (10 mu g/kg) around the expected peak of plasma corticosterone concentrations. In Expt. 2, one high doseof each of the three glucocorticoids was administered 4 hr before thepeak, followed by AVP stimulation around the expected peak of plasma corticosterone concentrations each day for 3 days. In Expt. 3, the recovery of the PA system following long-term daily administration of 1 mg/kg dexamethasone was investigated by repeated stimulations with AVP after cessation of the treatment. The results of these experiments (I)confirm that the PA system of pigeons is very sensitive to the suppressive effects of dexamethasone, cortisol, and prednisolone in a dose-dependent manner, (II) demonstrate that after cessation of glucocorticoid treatment the response to AVP stimulation is restored earlier than basal corticosterone concentrations, (III) demonstrate thar after long-term glucocorticoid treatment the responsiveness of the PA system recovers relatively fast, and (IV) demonstrate that long-term treatment with a high dose of dexamethasone not only results in complete suppression of the PA system but is also a serious risk for infection and death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:04:31