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Titolo:
EFFECTS OF EMBRYO-TRANSFER AND CORTICAL ECTOPIAS UPON THE BEHAVIOR OFBXSB-YAA AND BXSB-YAA PLUS MICE
Autore:
DENENBERG VH; SHERMAN G; SCHROTT LM; WATERS NS; BOEHM GW; GALABURDA AM; MOBRAATEN LE;
Indirizzi:
UNIV CONNECTICUT,BIOBEHAV SCI GRAD DEGREE PROGRAM,U-154 STORRS CT 06269 UNIV CONNECTICUT,DEPT PSYCHOL STORRS CT 06269 BETH ISRAEL HOSP,DYSLEXIA RES LAB BOSTON MA 02215 BETH ISRAEL HOSP,CHARLES A DANA RES INST BOSTON MA 02215 HARVARD UNIV,SCH MED,BETH ISRAEL HOSP,DEPT NEUROL,BEHAV NEUROL UNIT BOSTON MA 02215 JACKSON LAB BAR HARBOR ME 04609
Titolo Testata:
Developmental brain research
fascicolo: 1-2, volume: 93, anno: 1996,
pagine: 100 - 108
SICI:
0165-3806(1996)93:1-2<100:EOEACE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL DYSLEXIA; NEOCORTICAL ECTOPIAS; AUTOIMMUNE MICE; ABNORMALITIES; ANOMALIES; MOUSE;
Keywords:
AUTOIMMUNITY; CONGENIC STRAIN; CORTICAL ECTOPIA; DISCRIMINATION LEARNING; EMBRYO TRANSFER; LASHLEY MAZE; MORRIS MAZE; SPATIAL LEARNING; Y CHROMOSOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
V.H. Denenberg et al., "EFFECTS OF EMBRYO-TRANSFER AND CORTICAL ECTOPIAS UPON THE BEHAVIOR OFBXSB-YAA AND BXSB-YAA PLUS MICE", Developmental brain research, 93(1-2), 1996, pp. 100-108

Abstract

The BXSB-Yaa and BXSB-Yaa + inbred strains of mice differ primarily with respect to the Y chromosome, although there is evidence that they differ on several autosomal genes as well. Each strain has ectopic collections of neurons in neocortical layer I (ectopias), with a higher occurrence in males (58%) than females (42%). Conventionally reared mice from these strains were compared to mice that were transferred, as 8-cell embryos, into the uteri of non-autoimmune recipients, who gave birth to and reared the offspring. The transfer procedure did not change the incidence of ectopias in either sex. There were, however, major differences in behavior. Compared to conventionally reared controls, embryo transfer mice had greater behavioral asymmetry, poorer performance in a black-white discrimination, poorer Morris maze learning, batter Lashley maze learning, and better performance in a two-way shuttlebox. Within the transfer groups, females differed as much as males, confirming our prior findings and supporting our thesis that the two strains differ on several autosomal genes in addition to the Y chromosome. These findings show that the intra-uterine environment can powerfully and selectively affect later behavior. When ectopic and non-ectopic mice were compared, BXSB-Yaa mice with neocortical ectopias were better able to learn the Morris spatial maze than non-ectopic controls; this was true whether the mice were conventionally reared or embryo transferred. In contrast, BXSB-Yaa + ectopic mice did not differ from their controls if conventionally reared, but were much worse than controls ifembryo transferred.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 20:24:30