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Titolo:
DEVELOPMENTAL-CHANGES IN DEPOLARIZATION-MEDIATED AMPA RECEPTOR MODIFICATIONS AND POTASSIUM-INDUCED LONG-TERM POTENTIATION
Autore:
CHABOT C; BERNARD J; NORMANDIN M; OHAYON M; BAUDRY M; MASSICOTTE G;
Indirizzi:
UNIV QUEBEC,DEPT CHIM BIOL,CP 500 TROIS RIVIERES PQ G9A 5H7 CANADA UNIV QUEBEC,DEPT CHIM BIOL TROIS RIVIERES PQ G9A 5H7 CANADA CTR RECH FERNAND SEGUIN MONTREAL PQ H1N 3M5 CANADA UNIV SO CALIF,PROGRAM NEUROSCI LOS ANGELES CA 90089 INST PHILIPPE PINEL,CTR RECH MONTREAL PQ H1C 1H1 CANADA
Titolo Testata:
Developmental brain research
fascicolo: 1-2, volume: 93, anno: 1996,
pagine: 70 - 75
SICI:
0165-3806(1996)93:1-2<70:DIDARM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC TRANSMISSION; RAT HIPPOCAMPUS; PHOSPHOLIPASE-A2 TREATMENT; BROMOPHENACYL BROMIDE; NMDA RECEPTORS; ACID RELEASE; BINDING; INDUCTION; QUISQUALATE; EXPRESSION;
Keywords:
LONG-TERM POTENTIATION; DEVELOPMENT; PHOSPHOLIPASE; SYNAPTONEUROSOME; GLUTAMATE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C. Chabot et al., "DEVELOPMENTAL-CHANGES IN DEPOLARIZATION-MEDIATED AMPA RECEPTOR MODIFICATIONS AND POTASSIUM-INDUCED LONG-TERM POTENTIATION", Developmental brain research, 93(1-2), 1996, pp. 70-75

Abstract

In the present study, we examined the KC1-induced increase in H-3]amino-3-hydroxy-5-methylisoxazole-4-propionate ([H-3]AMPA) binding in telencephalic synaptoneurosomes and potentiation of synaptic transmission(KLTP) in hippocampal slices during development in rats. As previously reported, KC1-induced depolarization of telencephalic synaptoneurosomes resulted in a 40 +/- 5% increase in [H-3]AMPA binding to membrane fractions in adult rats (3 months old). KC1-induced increase in [H-3]AMPA binding was reduced to 24 +/- 5% and 15 +/- 5% at postnatal days (PND) 25-30 and PND 15-20 respectively, and was only 6 +/- 5% at PND 5-10. KLTP in area CA1 of hippocampus was most pronounced in adult slices (40 +/- 5%), and was reduced to 30 +/- 5% in slices prepared from PND 25-30 animals; KC1-induced LTP was absent in CA1 hippocampal slices prepared from PND 5-10 animals (3 +/- 5%). The decrease in KC1-inducedchanges in AMPA receptor binding in young animals was also associatedwith an altered capacity of the bee venom peptide, mellitin (a phospholipase A(2) (PLA(2)) activator), to increase [H-3]AMPA binding in synaptoneurosomes. The smaller effect of mellitin on [H-3]AMPA binding inyoung animals was not due to a decreased ability of this peptide to release [H-3]arachidonate from synaptoneurosomes. The parallel modifications in the extent of depolarization-induced change in AMPA receptor binding and excitatory synaptic transmission during development further support the hypothesis that alterations in AMPA receptor properties may play a critical role in synaptic plasticity.

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Documento generato il 20/01/21 alle ore 02:59:20