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Titolo:
EFFECT OF ALOIN, A QUINONE DERIVATIVE OF ALOE, ON ETHANOL-METABOLISM IN THE RAT
Autore:
CHUNG JH; CHEONG JC; PARK KS; ROH HK; CHA YN;
Indirizzi:
SEOUL NATL UNIV,COLL PHARM SEOUL 151742 SOUTH KOREA INHA UNIV,SCH MED INCHON 402751 SOUTH KOREA
Titolo Testata:
Medical science research
fascicolo: 6, volume: 24, anno: 1996,
pagine: 421 - 423
SICI:
0269-8951(1996)24:6<421:EOAAQD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD;
Keywords:
ALOE; ALOIN; QUINONES; ETHANOL METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Chung et al., "EFFECT OF ALOIN, A QUINONE DERIVATIVE OF ALOE, ON ETHANOL-METABOLISM IN THE RAT", Medical science research, 24(6), 1996, pp. 421-423

Abstract

Aloe contains aloin, a C-glycoside of anthraquinone. Based on recent reports indicating that the a extract of aloe enhances ethanol metabolism, and as quinones in general have a functional role in elevating the ethanol metabolism rate in vivo, we have attempted to identify the quinone derivative contained in aloe that was responsible. Upon oral administration of aloin (300 mg kg(-1)) 12 h before ethanol administration, the area under the curve (AUC) of blood ethanol significantly decreased by 40%, while the slope of elimination and rate of disappearancefrom the body increased by 60% and 64%, respectively. Based on these results, we conclude that aloin, localised in the skin of aloe, could be the substance in aloe that promotes ethanol metabolism in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:22:55