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Titolo:
PULMONARY SURFACTANT DYSFUNCTION IN CONGENITAL DIAPHRAGMATIC-HERNIA -EXPERIMENTAL AND CLINICAL FINDINGS
Autore:
VALLSISOLER A; ALFONSO LF; ARNAIZ A; ALVAREZ FJ; TOVAR JA;
Indirizzi:
HOSP CRUCES,DEPT PEDIAT,UNIDAD CUIDADOS INTENS NEONATALES,PLAZA CRUCES S-N E-48903 BARAKALDO BIZKAIA SPAIN UNIV BASQUE COUNTRY,HOSP CRUCES,SCH MED,DEPT PEDIAT,DIV NEONATOL BILBAO SPAIN UNIV BASQUE COUNTRY,HOSP CRUCES,SCH MED,DEPT PEDIAT,DIV PEDIAT SURG BILBAO SPAIN HOSP LA PAZ,DEPT PEDIAT SURG MADRID SPAIN
Titolo Testata:
Biology of the neonate
fascicolo: 5, volume: 69, anno: 1996,
pagine: 318 - 326
SICI:
0006-3126(1996)69:5<318:PSDICD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR ABNORMALITIES; LUNG DEVELOPMENT; MODEL; PATHOPHYSIOLOGY; HYPOPLASIA; NITROFEN; RATS; THERAPY; CDH;
Keywords:
CONGENITAL DIAPHRAGMATIC HERNIA; PULMONARY HYPOPLASIA; LUNG IMMATURITY; SURFACTANT THERAPY; PRENATAL DEXAMETHASONE TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
A. Vallsisoler et al., "PULMONARY SURFACTANT DYSFUNCTION IN CONGENITAL DIAPHRAGMATIC-HERNIA -EXPERIMENTAL AND CLINICAL FINDINGS", Biology of the neonate, 69(5), 1996, pp. 318-326

Abstract

Experimental and clinical findings indicate immaturity of pulmonary surfactant in congenital diaphragmatic hernia (CDH). Lung histology hasshown a decreased amount of lamellar bodies. A low lecithin/sphingomyelin ratio in the amniotic fluid, and decreased concentrations of surfactant protein A and disaturated phosphatidylcholine in the pulmonary tissue and the amniotic fluid have been reported. Furthermore, low compliance and high surface tension have also been found, Evidence of clinical and experimental findings of structural, biochemical and functional pulmonary immaturity in CDH is reviewed. Prenatal administration of corticosteroids to accelerate fetal pulmonary maturation, and the use of early surfactant therapy, should be further evaluated in the clinical management of CDH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:56:47