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Titolo:
PET ANALYSIS OF A CASE OF CEREBROTENDINOUS XANTHOMATOSIS PRESENTING HEMIPARKINSONISM
Autore:
KUWABARA K; HITOSHI S; NUKINA N; ISHII K; MOMOSE T; KUBOTA S; SEYAMA Y; KANAZAWA I;
Indirizzi:
UNIV TOKYO,FAC MED,INST BRAIN RES,DEPT NEUROL,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,FAC MED,INST BRAIN RES,DEPT NEUROL,BUNKYO KU TOKYO 113 JAPAN TOKYO METROPOLITAN INST GERONTOL,POSITRON MED CTR TOKYO JAPAN UNIV TOKYO,FAC MED,DEPT RADIOL TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT PHYSIOL CHEM & NUTR TOKYO 113 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1-2, volume: 138, anno: 1996,
pagine: 145 - 149
SICI:
0022-510X(1996)138:1-2<145:PAOACO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MRI;
Keywords:
CEREBROTENDINOUS XANTHOMATOSIS; HEMIPARKINSONISM; CHOLESTANOL; POSITRON EMISSION TOMOGRAPHY; [C-11] N-METHYLSPIPERONE; [F-18] 6-FLUORO-L-DOPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
K. Kuwabara et al., "PET ANALYSIS OF A CASE OF CEREBROTENDINOUS XANTHOMATOSIS PRESENTING HEMIPARKINSONISM", Journal of the neurological sciences, 138(1-2), 1996, pp. 145-149

Abstract

We describe a 33-year-old Japanese woman presenting gait difficulty and Achilles tendon swelling. The patient was diagnosed as having cerebrotendinous xanthomatosis (CTX) based on the high serum cholestanol level and diminished enzymatic activity of 27-hydroxylase of fibroblastsfrom her skin. Her clinical presentation was atypical regarding the presence of hemiparkinsonism and absence of apparent cataract, dementia, and cerebellar ataxia. Although MRI studies could not detect any abnormality in the basal ganglia or midbrain, PET analysis using [F-18]-6-fluoro-L-dopa revealed reduced uptake of dopamine into the putamen, suggesting the impairment of presynaptic dopaminergic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:37:28