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Titolo:
NEUROPATHIC PAIN IN RATS IS ASSOCIATED WITH ALTERED NITRIC-OXIDE SYNTHASE ACTIVITY IN NEURAL TISSUE
Autore:
CHOI Y; RAJA SN; MOORE LC; TOBIN JR;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT ANESTHESIOL & CRIT CARE MED,600 N WOLFE ST,OSLER 304 BALTIMORE MD 21287 JOHNS HOPKINS UNIV,SCH MED,DEPT ANESTHESIOL & CRIT CARE MED BALTIMOREMD 21287 BOWMAN GRAY SCH MED,DEPT ANESTHESIA WINSTON SALEM NC 27157
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1-2, volume: 138, anno: 1996,
pagine: 14 - 20
SICI:
0022-510X(1996)138:1-2<14:NPIRIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLONGED CHEMICAL NOCICEPTION; NMDA-RECEPTOR ANTAGONIST; SCIATIC-NERVE INJURY; SPINAL-CORD; THERMAL HYPERALGESIA; DORSAL HORN; PERIPHERAL MONONEUROPATHY; MODEL; NEURONS; MK-801;
Keywords:
NERVE INJURY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; HYPERALGESIA; ALLODYNIA; SENSITIZATION; DORSAL HORN; DORSAL ROOT GANGLION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
Y. Choi et al., "NEUROPATHIC PAIN IN RATS IS ASSOCIATED WITH ALTERED NITRIC-OXIDE SYNTHASE ACTIVITY IN NEURAL TISSUE", Journal of the neurological sciences, 138(1-2), 1996, pp. 14-20

Abstract

Peripheral nerve injury may lead to a chronic neuropathic pain state thai results from an increase in excitability of central neurons, Thiscentral sensitization is mediated via an N-methyl-D-aspartic acid (NMDA) receptor and may involve the production of nitric oxide (NO), As NO is suggested to play a role in nociceptive transmission following nerve injury, we examined for altered NO synthase activity at multiple levels of peripheral and spinal neural tissue in a rat model of neuropathic pain. Peripheral neuropathy was induced in rats (N = 12) by ligation of the left L5 and Lb nerve roots. Six other rats had sham surgery. An ipsilateral decrease in paw withdrawal threshold to mechanical stimuli confirmed the presence of a neuropathic pain state. Samples oi the lumbar and thoracic spinal cords, L4, L5, and L6 dorsal root ganglia (DRGs), and the sciatic nel?les were obtained from the lesioned and contralateral sides al 2 and 4 weeks after neuropathic surgery (N = 6 per group). Tn the lumbar spinal cord, a bilateral decrease in nitric oxide synthase (NOS) activity was observed :! and 4 weeks after neuropathic surgery. NOS activity Ei as increased in the ipsilateral L5 and 6 DRGs 2 weeks following neuropathic surgery. An increase in NOS activity in the DRG ma! be an early mechanism for inducing more central changes, The bilaterally decreased NOS activity in the lumbar spinal cordmay be secondary to a negative feedback mechanism resulting from increased NO production in the spinal dor sal root ganglia. Multiple alterations in expression of NOS activity that occur in both peripheral andcentral processing may play a role in the pain behavior resulting fi om peripheral naive injury.

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Documento generato il 30/11/20 alle ore 03:07:49