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Titolo:
DIFFERENTIAL EFFICACIES OF DOPAMINE D1 RECEPTOR AGONISTS FOR STIMULATING ADENYLYL-CYCLASE IN SQUIRREL-MONKEY AND RAT
Autore:
IZENWASSER S; KATZ JL;
Indirizzi:
NIDA,ADDICT RES CTR,PSYCHOBIOL SECT,POB 5180 BALTIMORE MD 21224
Titolo Testata:
European journal of pharmacology. Molecular pharmacology section
fascicolo: 1, volume: 246, anno: 1993,
pagine: 39 - 44
SICI:
0922-4106(1993)246:1<39:DEODDR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS PROPERTIES; ASSAY METHOD; COCAINE; SUBTYPES; STRIATUM; AFFINITY;
Keywords:
DOPAMINE D1 RECEPTOR; ADENYLYL CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Izenwasser e J.L. Katz, "DIFFERENTIAL EFFICACIES OF DOPAMINE D1 RECEPTOR AGONISTS FOR STIMULATING ADENYLYL-CYCLASE IN SQUIRREL-MONKEY AND RAT", European journal of pharmacology. Molecular pharmacology section, 246(1), 1993, pp. 39-44

Abstract

Adenylyl cyclase activity was stimulated by dopamine to approximately200% over basal activity in both squirrel monkey caudate and rat caudate-putamen. The selective dopamine D1 receptor agonists SKF 82958, A68930, dihydrexidine, CY 208-243, and SKF 75670 each produced similar maximal stimulation across the two species. SKF 38393, SKF 81297, and 6-Br-APB, however, each had higher efficacy in rat than in monkey. These results suggest differences in dopamine D1 receptors in the two species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:17:20