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Titolo:
DYNAMIC CHANGES IN THE LYMPHOCYTE SUBPOPULATIONS OF PIG UTERINE LYMPH-NODES
Autore:
BISCHOF RJ; LEE R; LEE CS; MEEUSEN E;
Indirizzi:
ROYAL MELBOURNE HOSP,DEPT MED PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,CTR ANIM BIOTECHNOL,SCH VET SCI PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 3-4, volume: 51, anno: 1996,
pagine: 315 - 324
SICI:
0165-2427(1996)51:3-4<315:DCITLS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; T-CELLS; PREGNANCY; MURINE; UTERUS; SUPPRESSOR; INCREASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Bischof et al., "DYNAMIC CHANGES IN THE LYMPHOCYTE SUBPOPULATIONS OF PIG UTERINE LYMPH-NODES", Veterinary immunology and immunopathology, 51(3-4), 1996, pp. 315-324

Abstract

Cell subpopulations in local lymph nodes draining the uterine tissue of non-pregnant and pregnant pigs were examined by one- and two-colourimmunofluorescent staining and flow cytometry using a panel of monoclonal antibodies to pig leucocyte cell surface antigens. Significant changes were observed in the T and B lymphocyte subpopulations and in a subpopulation of non-T or B cells. Activation of lymphocytes in the uterine lymph nodes during cycling in non-pregnant gilts suggests a rolefor the local immune system in the normal physiology of the uterus. In non-pregnant sows there was evidence of an increase in the CD4/CD8(H) ratio and in the proportion of B cells in the uterine nodes when compared to gilts with no prior reproductive experience. Pregnancy was shown to induce further dramatic changes in the uterine lymph nodes withan escalation in the proportion of B cells from 48% to 88% and a further increase in the CD4/CD8(H) ratio. For the first time in swine, low-level CD2 expression is reported on a subpopulation of B cells which are activated during pregnancy. These results provide evidence that the local uterine immune system in pigs plays a role in reproduction andperhaps in the maintenance of normal pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:53:25