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Titolo:
TREATMENT-RESISTANT SCHIZOPHRENIA - CLINICAL-EXPERIENCE WITH NEW ANTIPSYCHOTICS
Autore:
BONDOLFI G; BAUMANN P; DUFOUR H;
Indirizzi:
HOP CERY,DUPA PRILLY SWITZERLAND
Titolo Testata:
European neuropsychopharmacology
, volume: 6, anno: 1996, supplemento:, 2
pagine: 21 - 25
SICI:
0924-977X(1996)6:<21:TS-CWN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-TREATMENT; CLOZAPINE; RISPERIDONE; CHLORPROMAZINE; HALOPERIDOL;
Keywords:
TREATMENT-RESISTANT SCHIZOPHRENIA; RISPERIDONE; CLOZAPINE; EXTRAPYRAMIDAL SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
G. Bondolfi et al., "TREATMENT-RESISTANT SCHIZOPHRENIA - CLINICAL-EXPERIENCE WITH NEW ANTIPSYCHOTICS", European neuropsychopharmacology, 6, 1996, pp. 21-25

Abstract

Approximately 20-30% of patients with schizophrenia are resistant to conventional neuroleptics (i.e. are treatment-resistant). Clozapine has been shown to be effective in a proportion of treatment-resistant cases and to have a low side effect profile. However, it can cause agranulocytosis, is sedative and has marked anticholinergic properties. Risperidone, which is effective in chronic schizophrenia and has a low side effect profile and does not require routine blood monitoring, was compared with clozapine in a double-blind comparative study in 86 treatment-resistant patients. Preliminary findings indicate that, at endpoint, risperidone and clozapine were almost equieffective (total PANSS, PANSS subscales and CGI). Both drugs caused few adverse effects, and the severity of extrapyramidal symptoms was no different in the two groups. It is concluded that risperidone could be another drug effective in treatment-resistant schizophrenia. Further, larger trials will be needed to confirm this.

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Documento generato il 29/11/20 alle ore 06:36:41