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Titolo:
CORTICOTROPIN-RELEASING (CRH) ACTIVITY OF THYMIC PEPTIDES ON CRH-INSENSITIVE CORTICOTROPIC TUMOR-CELLS
Autore:
GOYA RG; CASTRO MG; HANNAH MJ; SOSA YE; LOWRY PJ;
Indirizzi:
NATL UNIV LA PLATA,FAC MED,INIBIOLP,CC 455 RA-1900 LA PLATA ARGENTINA UNIV READING,DEPT BIOCHEM & PHYSIOL READING RG6 2AH BERKS ENGLAND
Titolo Testata:
Medicina
fascicolo: 2, volume: 53, anno: 1993,
pagine: 108 - 112
SICI:
0025-7680(1993)53:2<108:C(AOTP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE; THYMOPOIETIN; THYMOPENTIN; SECRETION; INVITRO; ACTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Goya et al., "CORTICOTROPIN-RELEASING (CRH) ACTIVITY OF THYMIC PEPTIDES ON CRH-INSENSITIVE CORTICOTROPIC TUMOR-CELLS", Medicina, 53(2), 1993, pp. 108-112

Abstract

A number of thymic preparations are known to stimulate corticotropin (ACTH) release from pituitary cells but it remains unclear whether this effect is mediated by the corticotropin-releasing hormone (CRH) receptor-associated pathway. We report here that thymosin fraction five (TF5), peptide MB-35 and possibly cal thymus histones can stimulate the release of ACTH from a CRH-insensitive variant of the mouse corticotropic cell line AtT20. The effective concentration range at which TF5 and MB-35 displayed their ACTH-releasing activity in a dose-dependent manner was 100 to 2 000 mug/ml and 10 to 100 ng/ml, respectively, whereas neither preparation induced a significant depletion of intracellularACTH stores. Our data suggest that thymosin peptides can stimulate ACTH release from corticotrophs by a CRH receptor-independent mechamism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:46:52