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Titolo:
MEASURING AGE-RELATED-CHANGES IN DOPAMINE D-2 RECEPTORS WITH C-11 RACLOPRIDE AND F-18 N-METHYLSPIROPERIDOL
Autore:
VOLKOW ND; WANG GJ; FOWLER JS; LOGAN J; GATLEY SJ; MACGREGOR RR; SCHLYER DJ; HITZEMANN R; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED,BLDG 490 UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 67, anno: 1996,
pagine: 11 - 16
SICI:
0925-4927(1996)67:1<11:MAIDDR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN; BINDING-SITES; POSITRON TOMOGRAPHY; SEROTONIN RECEPTORS; C-11 RACLOPRIDE; D4 RECEPTORS; PET; SCHIZOPHRENIA; DENSITY;
Keywords:
AGING; POSITRON EMISSION TOMOGRAPHY; STRIATUM; NEURODEGENERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "MEASURING AGE-RELATED-CHANGES IN DOPAMINE D-2 RECEPTORS WITH C-11 RACLOPRIDE AND F-18 N-METHYLSPIROPERIDOL", PSYCHIATRY RESEARCH-NEUROIMAGING, 67(1), 1996, pp. 11-16

Abstract

This study investigates the rate of age-related dopamine D-2 receptorloss as determined by positron emission tomography (PET) and C-11-raclopride and compares it with D-2 loss previously estimated with F-18-N-methylspiroperidol (NMS). Dopamine D-2 receptors were measured with C-11-raclopride in 24 healthy volunteers (24-73 years of age) using theratio of the distribution volume in striatum to that in cerebellum (B-max/K-d + 1). The results were compared with those obtained in 20 healthy male volunteers (20-49 years of age) in whom D-2 receptors were measured with NMS using the ratio index (slope of the striatum-to-cerebellum ratio as a function of time). Findings of correlational analysisbetween age and dopamine D-2 receptor availability were significant for both ligands. Estimates of dopamine D-2 receptor loss per decade corresponded to 7.9% for the C-11-raclopride study and 7.8% for the NMS study. Both ligands documented significant age-related decreases in dopamine D-2 receptors that occurred relatively early in life (40 years of age).

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Documento generato il 27/01/20 alle ore 13:53:49