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Titolo:
A COMPARISON OF AN ATYPICAL AND TYPICAL ANTIPSYCHOTIC, ZOTEPINE VERSUS HALOPERIDOL IN PATIENTS WITH ACUTE EXACERBATION OF SCHIZOPHRENIA - APARALLEL-GROUP DOUBLE-BLIND TRIAL
Autore:
PETIT M; RANIWALLA J; TWEED J; LEUTENEGGER E; DOLLFUS S; KELLY F;
Indirizzi:
KNOLL PHARMACEUT,DEPT CLIN RES,E50,EVELYN ST NOTTINGHAM ENGLAND KNOLL PHARMACEUT,DEPT CLIN RES NOTTINGHAM ENGLAND UNIV ROUEN,DEPT PSYCHIAT,CHS ROUVRAY ROUEN FRANCE LABS KNOLL FRANCE SA LEVALLOIS PERRET FRANCE CHU COTE NACRE,CTR PSYCHIAT ESQUIROL CAEN FRANCE
Titolo Testata:
Psychopharmacology bulletin
fascicolo: 1, volume: 32, anno: 1996,
pagine: 81 - 87
SICI:
0048-5764(1996)32:1<81:ACOAAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTICS; SYMPTOMS; DRUGS;
Keywords:
ANTIPSYCHOTIC; ATYPICAL; HALOPERIDOL; SCHIZOPHRENIA; ZOTEPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Petit et al., "A COMPARISON OF AN ATYPICAL AND TYPICAL ANTIPSYCHOTIC, ZOTEPINE VERSUS HALOPERIDOL IN PATIENTS WITH ACUTE EXACERBATION OF SCHIZOPHRENIA - APARALLEL-GROUP DOUBLE-BLIND TRIAL", Psychopharmacology bulletin, 32(1), 1996, pp. 81-87

Abstract

The atypical antipsychotic zotepine was compared to haloperidol in 126 patients suffering from acute exacerbation of schizophrenia (DSM-III-R) in a randomized, double-blind study. After 8-weeks, 150 to 300 mg zotepine improved scores on the Brief Psychiatric Rating Scale (BPRS) more than 10 to 20 mg haloperidol (-17.03 versus -13.45; 95% Cl for zotepine-haloperidol -9.34/2.04). BPRS subscores and Clinical Global Impressions (CGI) Severity and Improvement subscales showed comparable gains, but scores on the Scale for the Assessment of Negative Symptoms (SANS) improved significantly more with zotepine (-23.82) than haloperidol (-15.15; p<.05; 95% Cl for zotepine-haloperidol -18.03/-0.18), Adverse events were reported by 71 percent of zotepine and 78 percent of haloperidol patients, Extrapyramidal side effect (EPMS) scores decreased with zotepine (-0.34) but increased with haloperidol (+2.32; p<.05). Seven haloperidol patients reported akathisia but no zotepine patients did (p<.05), Uric acid reductions (which appear to have no clinicalconsequence) and transient raised liver enzymes were recorded with zotepine, Weight increased on zotepine (2.32 kg; p<.001) and a small increase in pulse rate occurred (p<.05). Both drugs were effective in reducing positive symptoms of schizophrenia; zotepine was significantly more effective against negative symptoms and reduced EPMS.

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Documento generato il 25/01/20 alle ore 18:41:30