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Titolo:
IMMUNOHISTOCHEMICAL STAINING OF DESMOSOMAL COMPONENTS IN ORAL SQUAMOUS-CELL CARCINOMAS AND ITS ASSOCIATION WITH TUMOR BEHAVIOR
Autore:
HIRAKI A; SHINOHARA M; IKEBE T; NAKAMURA S; KURAHARA S; GARROD DR;
Indirizzi:
KYUSHU UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812 JAPAN KYUSHU UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG,HIGASHI KU FUKUOKA 812 JAPAN UNIV MANCHESTER,SCH BIOL SCI MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 12, volume: 73, anno: 1996,
pagine: 1491 - 1497
SICI:
0007-0920(1996)73:12<1491:ISODCI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE METASTASIS; MONOCLONAL-ANTIBODY; URINARY-BLADDER; DESMOPLAKIN-II; INVASION; CLASSIFICATION; GLYCOPROTEIN; EXPRESSION; PATHOLOGY; MODE;
Keywords:
ORAL SQUAMOUS CELL CARCINOMA; DESMOSOMAL PROTEINS; DESMOSOMAL GLYCOPROTEIN; DESMOGLEIN; DESMOPLAKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Hiraki et al., "IMMUNOHISTOCHEMICAL STAINING OF DESMOSOMAL COMPONENTS IN ORAL SQUAMOUS-CELL CARCINOMAS AND ITS ASSOCIATION WITH TUMOR BEHAVIOR", British Journal of Cancer, 73(12), 1996, pp. 1491-1497

Abstract

Desmosomes are intercellular junctions that have been shown to be down-regulated in certain types of carcinomas and that may play a role insuppression of invasion and metastasis. We have shown previously thatimmunohistochemical staining for the major desmosomal glycoprotein, desmoglein (Dsg), is reduced in some cases of squamous cell carcinoma (SCC) of the head and neck, and that reduced staining correlates with lymph node involvement. Desmosomes are multicomponent organelles. We therefore sought to determine whether another major desmosomal molecule,desmoplakin (Dp), showed similar reduced expression to that shown by desmoglein. We have stained 65 specimens of primary SCC of the oral cavity (37 non-metastatic and 28 metatastic) with monoclonal antibodies to both desmoglein and desmoplakin. We show that reduction of Dp staining correlates with loss of differentiation of the primary tumour, degree of invasion and presence of lymph node metastases. Similar correlations were found with Dsg staining. There was also correlation betweenreduction in Dp staining and reduction in Dsg staining. It is concluded that down-regulation of desmosomal expression occurs in some cases of SCC of the oral cavity and is associated with invasion and metastasis. Desmosomes may have an invasion and metastasis suppressor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:23:27