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Titolo:
THYROID NODULARITY AFTER DIAGNOSTIC ADMINISTRATION OF I-131
Autore:
HALL P; FURST CJ; MATTSSON A; HOLM LE; BOICE JD; INSKIP PD;
Indirizzi:
KAROLINSKA HOSP,DEPT ONCOL,RADIUMHEMMET S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,CTR ONCOL S-17176 STOCKHOLM SWEDEN SWEDISH RADIAT PROTECT INST STOCKHOLM SWEDEN NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,RADIAT EPIDEMIOL BRANCH BETHESDA MD 20892 TEXAS A&M UNIV,COLL VET MED COLLEGE STN TX 77843
Titolo Testata:
Radiation research
fascicolo: 6, volume: 146, anno: 1996,
pagine: 673 - 682
SICI:
0033-7587(1996)146:6<673:TNADAO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER INCIDENCE; RADIATION; CHERNOBYL; I-131; CHILDHOOD; NODULES; FALLOUT; HYPERTHYROIDISM; NEOPLASIA; GLANDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P. Hall et al., "THYROID NODULARITY AFTER DIAGNOSTIC ADMINISTRATION OF I-131", Radiation research, 146(6), 1996, pp. 673-682

Abstract

In contrast to external X and gamma radiation, radiation from internally deposited I-131 has not been clearly shown to cause thyroid tumorsor nodules. Given the wide use of I-131 in medicine and concern abouthealth risks associated with the release of radioiodines from nuclearreactors, more information is needed. The purpose of this study was to evaluate the risk of thyroid nodularity among women previously exposed to radioiodine (I-131) for diagnostic reasons. A clinical examination survey, including thyroid palpation, was conducted for a sample of women drawn from a cohort of patients exposed to I-131 and a comparison group of women attending a mammography screening clinic. The study was conducted during 1991-1993 at Radiumhemmet, Karolinska Hospital, Stockholm, Sweden. A total of 1,005 women referred for a thyroid scintigraph or tracer test during the period 1952-1977 were included in the study. For comparison, 248 nonexposed women attending a mammography screening clinic were also enrolled. The primary outcome measure was the presence or absence of palpable thyroid nodules at the time of the clinical examination. Odds ratios were used as estimates of relative risk(RR). The mean dose to the thyroid from I-131 was 0.54 Gy, and the average age at I-131 administration was 26 years. The prevalence of thyroid nodularity was 10.6% among women who had been exposed to I-131 and11.7% among the nonexposed women [RR = 0.9; 95% confidence interval (CI) 0.6-1.4]. When analysis was restricted to women exposed to I-131, prevalence was associated positively with thyroid dose (excess RR = 0.9 per Gy; 95% CI 0.2-1.9). However, the excess RR was similar for women exposed before age 20 years and those exposed after age 20, which iscontrary to findings for populations exposed to external radiation. While results demonstrated a positive association between diagnostic administration of I-131 and the subsequent occurrence of thyroid nodules, it is unclear whether the association is causal, as the possibility of confounding by indication for I-131 administration cannot be ruled out. No tumors that were subsequently diagnosed as cancer were found during the thyroid examinations, which supports the view that exposure to I-131 administered for diagnostic reasons during adulthood rarely causes thyroid cancer. (C) 1996 by Radiation Research Society

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Documento generato il 07/07/20 alle ore 11:34:33