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Titolo:
DECREASED RAT-BRAIN CYTOCHROME-OXIDASE ACTIVITY AFTER PROLONGED HYPOXIA
Autore:
LAMANNA JC; KUTINANELSON KL; HRITZ MA; HUANG ZF; WONGRILEY MTT;
Indirizzi:
CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROL,10900 EUCLID AVE CLEVELAND OH 44106 MED COLL WISCONSIN,DEPT CELLULAR BIOL & ANAT MILWAUKEE WI 53226
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 720, anno: 1996,
pagine: 1 - 6
SICI:
0006-8993(1996)720:1-2<1:DRCAAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHERMIA; TISSUE; CORTEX;
Keywords:
CYTOCHROME OXIDASE HISTOCHEMISTRY; HYPOBARIC HYPOXIA; HYPOMETABOLISM; HYPOXIC ADAPTATION; BRAIN ENERGY METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Lamanna et al., "DECREASED RAT-BRAIN CYTOCHROME-OXIDASE ACTIVITY AFTER PROLONGED HYPOXIA", Brain research, 720(1-2), 1996, pp. 1-6

Abstract

Three weeks of hypoxic exposure results in a spectrum of systemic physiological and local brain tissue adaptations. Cytochrome oxidase histochemistry was used as an indicator of changes in energy demand in response to hypoxia. We found overall cytochrome oxidase activity decreased in hypoxic adapted rats as compared to normoxic control rats. Some regions, notably layer 3 of the frontal cerebral cortex, layer 4 of the parietal sensory barrel fields, lacunosum moleculare hippocampi, andspecific nuclei of the rostral ventral medulla, though exhibiting cytochrome oxidase activity decreases of 16-27%, still retain their relatively higher levels of activity. We conclude that there is a hypometabolic component of the rat brain adaptation to continued hypoxia.

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Documento generato il 25/01/20 alle ore 18:39:32