Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INVOLVEMENT OF PLATELET-ACTIVATING-FACTOR IN CYTOKINE PRODUCTION AND NEUTROPHIL ACTIVATION AFTER HEPATIC ISCHEMIA-REPERFUSION
Autore:
SERIZAWA A; NAKAMURA S; SUZUKI S; BABA S; NAKANO M;
Indirizzi:
HAMAMATSU UNIV,SCH MED,DEPT SURG 2,3600 HANDA CHO HAMAMATSU SHIZUOKA 43131 JAPAN JAPAN IMMUNORES LABS CO LTD,DEPT PHOTON & FREE RAD RES TAKASAKI GUMMAJAPAN
Titolo Testata:
Hepatology
fascicolo: 6, volume: 23, anno: 1996,
pagine: 1656 - 1663
SICI:
0270-9139(1996)23:6<1656:IOPICP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; EPITHELIOID CELL-LINE; FACTOR-ALPHA; PROSTAGLANDIN-I2 ANALOG; INTERLEUKIN-8 FAMILY; ENDOTHELIAL-CELLS; FACTOR ANTAGONIST; PAF ANTAGONIST; KUPFFER CELLS; LUNG INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Serizawa et al., "INVOLVEMENT OF PLATELET-ACTIVATING-FACTOR IN CYTOKINE PRODUCTION AND NEUTROPHIL ACTIVATION AFTER HEPATIC ISCHEMIA-REPERFUSION", Hepatology, 23(6), 1996, pp. 1656-1663

Abstract

Although platelet-activating factor (PAF) is implicated as an important mediator in the pathogenesis of hepatic ischemia-reperfusion (IR) injury, the precise mechanism of its action has not been studied. We examined the hypothesis that PAF may influence neutrophils by promoting the production of tumor necrosis factor alpha (TNF-alpha) and cytokine-induced neutrophil chemoattractant (CINC), a member of the interleukin-8 (IL-8) family, and may be associated with liver and lung injury during the early phase of reperfusion after total hepatic ischemia. Ratspretreated with a specific PAF receptor antagonist exhibited suppression of the increase in plasma TNF-alpha and CINC level, as well as thepriming of peripheral neutrophils for superoxide production after reperfusion when compared with animals pretreated with physiological saline. These effects resulted in a reduction of plasma Liver enzymes and of hepatic and pulmonary neutrophil sequestration, as well as an increased survival rate. There was a strong correlation between the time course of CINC release and hepatic or pulmonary neutrophil sequestration. We concluded that PAF activates neutrophils, either directly or by promoting the production of TNF-alpha and CINC, and is involved in hepatic IR injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:51:37